Wee1 Kinase Inhibitor AZD1775 Effectively Sensitizes Esophageal Cancer to Radiotherapy.

CONCLUSIONS: Abrogation of G2/M checkpoint by targeting Wee1 kinase with AZD1775 sensitizes ESCA cells to radiotherapy in vitro and in mouse xenografts. Our findings suggest that inhibition of Wee1 by AZD1775 is an effective strategy for radiosensitization in esophageal cancer and warrants clinical testing.
PMID: 32220892 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - March 26, 2020 Category: Cancer & Oncology Authors: Yang L, Shen C, Pettit CJ, Li T, Hu AJ, Miller ED, Zhang J, Lin SH, Williams TM Tags: Clin Cancer Res Source Type: research