IgG4-Related Disease and Allergen Specific Immunotherapy

IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder named upon the prominent IgG4+ plasma cells infiltrate in affected organs1-4. The aetiology of IgG4-RD is unknown and the pathogenicity of IgG4 antibodies remains a matter of a live debate1-5. In general, IgG4 antibodies are believed to dampen chronic inflammation thanks to their anti-inflammatory properties1. Yet, injection of patient derived IgG4 in mice induce IgG4-RD-like lesions, suggesting that IgG4 antibodies can cause tissue damage1.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research