5,6-Dihydro- α-pyrones from the leaves of Cryptocarya pulchinervia (Lauraceae)

AbstractThree new 5,6-dihydro- α-pyrones derivatives, named (S)-rugulactone (1) pulchrinervialactone A (2), and pulchrinervialactone B (4), along with one known pyrone, cryptobrachytone C (3), and three known amide derivatives (5 –7) have been isolated from the leaves ofCryptocarya pulchrinervia. The structures of1 –7 were elucidated based on extensive spectroscopic data and comparison with literatures. The configurations of compounds3 and 4 were established by single crystal X-ray diffraction analysis. This is also the first report in finding (S)-rugulactone (1) as a natural product. In addition, the preliminary cytotoxic activity of the isolated compounds was evaluated against P-388 cells using the [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. All the pyrones, except compound4, were active significantly inhibiting the growth of P-388 cells, while the amides derivatives (5 –7) showed moderate to weak activities. Therefore, compounds1 –3 could be potentially examined further for anticancer agents.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research