Biomarkers and their potential functions in idiopathic pulmonary fibrosis.

Biomarkers and their potential functions in idiopathic pulmonary fibrosis. Expert Rev Respir Med. 2020 Mar 18;: Authors: Ni S, Peng H, Song M, Guo W, Guo T, Shen Q Abstract Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating, and progressive lung disease which is characterized by fibrosis and respiratory failure. IPF holds high morbidity and poor prognosis and still faces with considerable problems of reliable diagnosis and valid prognosis. A growing body of literatures have reported changes in the level of various biomarkers in IPF patients, which means that they are expected to become a new tool for clinical practice of IPF.Areas covered: We reviewed the recent literature about biomarkers and focus on the role they play in IPF. We systematically searched Medline/PubMed through February 2020. Many literatures have showed that a variety of biomolecules and genomics played multiple roles in the diagnosis or differential diagnosis, prognosis, and indication of acute deterioration of IPF and so on.Expert opinion: Significant advances have been made in the role of biomarkers for IPF these years, however, current data indicate that a single biomarker is unlikely to have a transformative effect on clinical practice, therefore, the combined effect of various biomarkers can be considered to improve the accuracy of diagnosis and prognosis. Further research of biomarkers may provide new insights for the diagnosis, progn...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research