This Month in Investigative Urology

MALAT-1, a long noncoding RNA, was described as a regulator of metastasis and motility, and is over expressed in various human solid tumors. In this issue of The Journal Ren et al (page 2278) from the People's Republic of China evaluated MALAT-1 expression in prostate cancer tissues and cell lines, and studied the therapeutic effects of MALAT-1 silencing on castration resistant prostate cancer (CRPC) cells in vitro and in vivo. Quantitative reverse transcriptase-polymerase chain reaction was done to detect MALAT-1 expression and examine the silencing effect of siRNA designed against MALAT-1. The biological effects of MALAT-1 siRNA on cells were investigated by examining cell proliferation, cell colony assay, cell migration, cell invasion and the cell cycle. The effect of therapeutic siRNA targeting MALAT-1 on CRPC was also studied in vivo.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research