UCSF features expertise in kidney care and work on artificial kidney

More than 37 million Americans are living with chronic kidney disease. Almost 750,000 Americans are dealing with the stark reality of end stage renal disease (ESRD), when their kidneys no longer function well enough to sustain life on their own.
Source: UCSF School of Pharmacy News - Category: Universities & Medical Training Source Type: news

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Post-lung transplantation (post-LTx) progressive chronic kidney disease (CKD) is associated with increased morbidity and mortality.1 Comorbidities and cotreatments, and post-LTx medical complications, including acute kidney injury (AKI), are associated with an increased risk for subsequent CKD development.2 However, among the several risk factors for post-LTx CKD development, pre-transplant renal function plays a key role.3
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research Correspondence Source Type: research
This study, for instance, attributes a patient’s waitlist/transplant outcome to the very last dialysis facility the patient was associated with.  In epidemiology speak, this means the causal inference authors are trying to draw between for-profit status and good transplant outcomes is subject to time-varying confounding. As an example, if one is seeking an association between testosterone levels and risk of a heart attack, using the last testosterone level available would be a poor way of doing this study because testosterone levels are known to vary over time. The same applies to dialysis facilities. Patie...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Physicians Eric Weinhandl JAMA medical research public health Public Policy public policy research Source Type: blogs
Arterial stiffness and kidney disease progression in the systolic blood pressure intervention trial
. Clin Nephrol. 2020 May 25;: Authors: Nowak KL, Chonchol M, Jovanovich A, You Z, Ambrosius WT, Cho ME, Glasser S, Lash J, Simmons DL, Taylor A, Weiner D, Rastogi A, Oparil S, Supiano MA Abstract AIMS: Arterial stiffness increases with both advancing age and chronic kidney disease (CKD) and may contribute to kidney function decline, but evidence is inconsistent. We hypothesized that greater baseline arterial stiffness (assessed as pulse pressure (PP) and carotid-femoral pulse-wave velocity CFPWV)) was...
Source: Clinical Nephrology - Category: Urology & Nephrology Authors: Tags: Clin Nephrol Source Type: research
Bioelectrical impedance analysis (BIA) and anthropometric predictive equations have been proposed to estimate whole-body (SMM) and appendicular skeletal muscle mass (ASM) as surrogate for dual energy X-ray absorptiometry (DXA) in distinct population groups. However, their accuracy in estimating body composition in non-dialysis dependent patients with chronic kidney disease (NDD-CKD) and kidney transplant recipients (KTR) is unknown. The aim of this study was to investigate the accuracy and reproducibility of BIA and anthropometric predictive equations in estimating SMM and ASM compared to DXA, in NDD-CKD patients and KTR.
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Original article Source Type: research
Conclusion: The donor corneas retrieved from chronic kidney disease patients are safe and suitable for optical keratoplasty provided they meet the criteria for transplantation.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Decreasing or eliminating time on dialysis and expediting kidney transplant are prime objectives when caring for chronic kidney disease sufferers,1 particularly since longer wait times on dialysis are associated with higher mortality rates. While influence of online patient portal (OPP) participation has been studied in other patient populations,2,3 and other tools of patient engagement have been evaluated in transplant candidates on the waitlist,4 this is the first study focused on OPP in waitlist kidney candidates and its effect on kidney transplantation wait time.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Invited commentary Source Type: research
Health systems are under pressure to deliver more effective care without expansion of resources. This is particularly pertinent to diseases like chronic kidney disease (CKD) that are exacting substantial finan...
Source: Cost Effectiveness and Resource Allocation - Category: Health Management Authors: Tags: Review Source Type: research
This report describes the case of a patient under peritoneal dialysis (PD) due to chronic kidney disease secondary to focal segmental glomerulosclerosis diagnosed with EPS. The patient had undergone two living-donor kidney transplant procedures. Surgical techniques and clinical measures employed to unravel bowel obstruction are described, which have been shown to ameliorate EPS secondary complications. Parenteral nutrition has significantly contributed to afford adequate nutrition, improving tissue healing as well as serum protein levels, vitamins and electrolytes. Therapy with tamoxifen and sodium thiosulfate effectively ...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
The objective of the systematic review is to assess the long-term renal outcomes of allopurinol compared with febuxostat in patients with hyperuricemia and CKD or kidney transplantation. PubMed MEDLINE, Embase, Web of Science, Scopus, and Cochrane CENTRAL databases were searched from inception to December 2019 using the key terms “allopurinol,” “febuxostat,” “xanthine oxidase inhibitors,” “gout suppressants,” “hyperuricemia,” “gout,” “chronic renal insufficiency,” and “kidney transplantation.” Studies with follow-up duration &ge...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractPurpose of reviewTo discuss the latest on the definition of acute kidney injury (AKI), its pathophysiology and treatment of the condition.Recent findingsAKI in cirrhosis includes both functional and structural causes. Type 1 hepatorenal syndrome is a special form of functional AKI (HRS-AKI) associated with a very poor prognosis. The pathophysiology of AKI involves hemodynamic changes as well as inflammation. The treatment for AKI is mostly designed for HRS-AKI using albumin and vasoconstrictors to improve systemic hemodynamics, hence renal perfusion and function, resulting in a response rate of up to 44%. Otherwise...
Source: Current Treatment Options in Gastroenterology - Category: Gastroenterology Source Type: research
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