Megalin in acute kidney injury - foe and friend.

Megalin in acute kidney injury - foe and friend.
Am J Physiol Renal Physiol. 2013 Nov 6;
Authors: Mahadevappa R, Nielsen R, Christensen EI, Birn H
Abstract
The kidney proximal tubule is a key target in many forms of acute kidney injury (AKI). The multiligand receptor megalin is responsible for the normal proximal tubule uptake of filtered molecules, including nephrotoxins, cytokines, and markers of AKI. By mediating uptake of nephrotoxins megalin plays an essential role in the development of some types of AKI. However, megalin also mediates the tubular uptake of molecules implicated in the protection against AKI, and changes in megalin expression have been demonstrated in AKI in animal models. Thus, modulation of megalin expression in response to AKI may be an important part of the tubule cell adaption to cellular protection and regeneration, and should be further investigated as a potential target of intervention. This review will explore current evidence linking megalin expression and function to the development, diagnosis, progression, and renal protection in AKI.
PMID: 24197071 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - November 6, 2013 Category: Urology & Nephrology Authors: Mahadevappa R, Nielsen R, Christensen EI, Birn H Tags: Am J Physiol Renal Physiol Source Type: research