Roles of Epithelial-mesenchymal Transition in Cancer Drug Resistance.

Roles of Epithelial-mesenchymal Transition in Cancer Drug Resistance.
Curr Cancer Drug Targets. 2013 Oct 29;
Authors: Shang Y, Cai X, Fan D
Abstract
Overcoming intrinsic and acquired drug resistance is a major challenge in treating cancer. Poor responses to drug treatment can result in metastasis, cancer dissemination and death. Recently, the epithelial-mesenchymal transition (EMT) has been found to play a critical role in cancer drug resistance, but the nature of this intrinsic link remains unclear. This review summarizes recent advances in the understanding of drug resistance and focuses especially on the association between EMT and drug resistance. We discuss the roles of EMT in regulating drug resistance across different types of cancer, focusing simultaneously on the molecular mechanisms and potential pathways involved in the regulation of drug resistance by EMT. In addition, we discuss potential therapeutic strategies to target EMT to reverse drug resistance.
PMID: 24168191 [PubMed - as supplied by publisher]

Source: Current Cancer Drug Targets - October 29, 2013 Category: Cancer & Oncology Authors: Shang Y, Cai X, Fan D Tags: Curr Cancer Drug Targets Source Type: research