Outcome Measures in Critical Care Nutrition Interventional Trials: A Systematic Review.

Outcome Measures in Critical Care Nutrition Interventional Trials: A Systematic Review.
Nutr Clin Pract. 2020 Mar 05;:
Authors: Chapple LS, Summers MJ, Weinel LM, Deane AM
Abstract
Historically, randomized controlled trials (RCTs) in critical care have used mortality as the primary outcome, yet most show no effect on this outcome. Therefore, there has been a shift in the literature to focus on alternative outcomes. This review aimed to describe primary outcomes selected in RCTs of nutrition interventions in critical illness. Systematic search of the literature identified RCTs of nutrition interventions in critically ill adults published between January 2007 and December 2018. Primary outcomes were documented and categorized as mortality, morbidity, health service/cost-effectiveness, or nutrition outcome. The direction of effect of the intervention on the primary outcome (positive, neutral, or negative) was extracted. Of 1163 citations identified and assessed for eligibility, 125 articles were included. However, 52 articles (42%) did not provide a sample-size calculation, leaving 73 articles (58%) for data extraction. The primary outcomes reported were morbidity (n = 24, 32.9%); health service/cost-effectiveness (n = 21, 28.8%); nutrition outcomes (n = 16, 21.9%); mortality (n = 11, 15.1%); and other (n = 1, 1.4%). No RCTs with mortality as the primary outcome reported a difference between intervention and control. Trials that include...

Source: Nutrition in Clinical Practice - March 4, 2020 Category: Nutrition Authors: Chapple LS, Summers MJ, Weinel LM, Deane AM Tags: Nutr Clin Pract Source Type: research