Adenosine-producing regulatory B cells in head and neck cancer

ConclusionOur data demonstrate the presence of a novel ADO-producing Breg population within the tumor microenvironment in mice and humans. A new model is proposed on how ADO-producing Breg can influence the function of Beff cells in healthy donors and cancer patients. Thus, the modulation of the ADO pathway in B cells may serve as a therapeutic approach for cancer patients.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research