Transient enhanced cell division by blocking DNA synthesis in Escherichia coli.

Transient enhanced cell division by blocking DNA synthesis in Escherichia coli. Microbiology. 2020 Mar 02;: Authors: Martín CM, Zaritsky A, Fishov I, Guzmán EC Abstract Duplication of the bacterial nucleoid is necessary for cell division hence specific arrest of DNA replication inhibits divisions culminating in filamentation, nucleoid dispersion and appearance of a-nucleated cells. It is demonstrated here that during the first 10 min however, Escherichia coli enhanced residual divisions: the proportion of constricted cells doubled (to 40%), nucleoids contracted and cells remodelled dimensions: length decreased and width increased. The preliminary data provides further support to the existence of temporal and spatial couplings between the nucleoid/replisome and the sacculus/divisome, and is consistent with the idea that bacillary bacteria modulate width during the division process exclusively. PMID: 32118529 [PubMed - as supplied by publisher]
Source: Microbiology - Category: Microbiology Authors: Tags: Microbiology Source Type: research