Does Pancreaticogastrostomy Reduce Risk of Postoperative Pancreatic Fistula After Pancreatoduodenectomy?
Pancreaticoduodenectomy is a complex operation that has become safer over the past 3 decades but is still associated with a high complication rate. Much of this morbidity is attributable to leakage of the pancreatic anastomosis and the ensuing postoperative pancreatic fistula (POPF), which contributes to deep-space infection, delayed gastric emptying, hemorrhage, and systemic complications, including septic shock, organ failure, and death. Many groups have sought to reduce the risk of POPF using novel anastomotic techniques, topical agents, and medical treatments. A fundamental technical variation is whether the pancreas is anastomosed to the jejunum or the stomach.
CONCLUSIONS: Thiol/disulphide homeostasis is impaired in patients with sepsis and septic shock. Understanding the role of thiol/disulphide homeostasis in sepsis and septic shock may provide different therapuetic intervention strategies for patients. PMID: 32233178 [PubMed - as supplied by publisher]
Publication date: Available online 1 April 2020Source: International Journal of Surgery Case ReportsAuthor(s): Victoria Lu, Harsh Kanhere
This study aimed to evaluate the association between hemodynamic and skin perfusion parameters and enteral nutrition therapy (NT) outcomes in septic shock patients.
No abstract available
Conclusions: SIRS can progress to septic shock if not identified early. The predictors of mortality were positive blood cultures, multiorgan dysfunction, late hospital admissions, severe acute malnutrition, and requirement of supportive care. The predictors of progression to septic shock were abnormal leukocyte count, culture positivity, and severe acute malnutrition.
Abstract Guidelines published in 2016 provide a revised definition of sepsis: life-threatening organ dysfunction caused by a dysregulated host response to infection. The guidelines define septic shock as sepsis with circulatory, cellular, and metabolic dysfunction that is associated with a higher risk of mortality. The measurement of serum lactate has been incorporated into the latest septic shock definition. The guidelines recommend the Sequential Organ Failure Assessment (original and quick versions) as an important tool for early diagnosis. Respiratory, gastrointestinal, genitourinary, and skin and soft tissue ...
Annals of the American Thoracic Society,Volume 17, Issue 4, Page 529-529, April 2020.
Sepsis is defined as dysregulated host response caused by systemic infection, leading to organ failure. It is a life-threatening condition, often requiring admission to an intensive care unit (ICU). The causative agents and processes involved are multifactorial but are characterized by an overarching inflammatory response, sharing elements in common with severe inflammatory response syndrome (SIRS) of non-infectious origin. Sepsis presents with a range of pathophysiological and genetic features which make clinical differentiation from SIRS very challenging. This may reflect a poor understanding of the key gene inter-activi...
Series Type : Expression profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Conclusion: This microarray-based approach unveiled the expression of about 87,912 distinct HERV probesets and identified 764 putative promoter LTRs and 642 putative polyA LTRs in whole blood. HERV/MaLR expression was shown to be tightly modulated in septic shock patients according to mHLA-DR expression. We identified a set of potential molecular biomarkers in septic shock patients partially overlapping immunosuppression (mHLA-DR), and the risk of Health Care associated Infections (HAI) (CD74 ratio), complementary to existing molecular markers of a sepsis patients stratification. We identified a HERV/MaLR signature discrim...