A Case of Hemophagocytic Lymphohistiocytosis following Refractory Kawasaki Disease
Klin Padiatr DOI: 10.1055/a-1110-7303Hemophagocytic lymphohistiocytosis (HLH) is a systemic inflammatory disorder
characterized by uncontrolled histiocytic proliferation, hemophagocytosis,
macrophage activation, and up-regulation of inflammatory cytokines (Grom AA.,
Current opinion in rheumatology 2003; 15: 587–590). HLH is usually divided
into two types: primary (familial) HLH and secondary (reactive) HLH. Primary HLH is
associated with primary immune deficiencies in which specific gene mutations play an
important role, such as perforin defects. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Klinische Padiatrie - Category: Pediatrics Authors: Li, Ye Wang, Yulong Li, Shen Liu, Mingjing Wang, Dingding Xu, Chaoyue Zhang, Luan Tags: Letter to the Editor Source Type: research