Reverse Sequence Syphilis Screening and Discordant Results in Pregnancy

A “reverse sequence syphilis screening” algorithm is widely used for syphilis testing. This retrospective study showed that most (65%) pregnant women with discordant screening results (treponemal multiplex flow immunoassay IgG+/rapid plasma reagin-) had a nonreactive confirmatory Treponema pallidu m-particle agglutination assay, likely indicative of a false-positive reaction.

Source: The Journal of Pediatrics - February 20, 2020 Category: Pediatrics Authors: Jessica E.P. Williams, Jos é A. Bazan, Abigail Norris Turner, Stephen F. Thung, Cory Hanlon, Tanisha R. Pettus, Pablo J. Sánchez Tags: Brief Reports Source Type: research