Long-term outcomes following total hip and total knee arthroplasty in patients with Paget's disease of bone (PDB) – A national study

ConclusionThis is the largest reported series of outcomes following primary THA/TKA in PDB patients. PDB patients are not at increased risk of surgical complications following primary THA or TKA compared with the general population.Graphical abstractAnteroposterior radiograph of the pelvis of patient with PDB and treated with a cemented total hip arthroplasty.
Source: The Surgeon - Category: Surgery Source Type: research

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ConclusionsPDB is often diagnosed through incidental findings in a regular blood chemistry panel, particularly ALK, or through imaging done for another reason. The planar radiograph gives the best clue to the presence of PDB. The MDCT is mandatory for better outcomes in treatment of osteosarcoma, whereas MRI is best for depicting local intracranial extension. PET identifies the region of a tumor through FDG increase. Lastly, biopsy is necessary for confirming the tumor.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionsOSCS is a rare disorder. Diagnosis can often be challenging because other diseases, such as osteopetrosis, pyknodysostosis, Paget disease of bone, and other sclerosing bone dysplasias, make this difficult to diagnose. Radiologists should be aware of the specific radiographic appearance of this condition to aid in the proper diagnosis and management of these patients.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
This study reviews an adult male (SK463) and female (SK750) with skeletal lesions of PDB from Poulton Chapel, Cheshire. Full macroscopic and radiographic analysis has identified the skeletal distribution of PDB, with up to 75% of both skeletons affected. SK463 presents noticeable anterior bowing to both tibiae, likely the result of PDB. AMS radiocarbon dating and stable isotope analysis performed on teeth samples confirmed that both individuals' dates were medieval, had a mixed/varied diet and were local to the northwest of England. This research adds to the emerging paleopathological literature on PDB, while providing add...
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
This study reviews an adult male (SK463) and female (SK750) with skeletal lesions of PDB from Poulton Chapel, Cheshire. Full macroscopic and radiographic analysis has identified the skeletal distribution of PDB, with up to 75% of both skeletons affected. SK463 presents noticeable anterior bowing to both tibiae, likely the result of PDB. AMS radiocarbon dating and stable isotope analysis performed on teeth samples confirmed that both individuals dates were medieval, had a mixed/varied diet and were local to the northwest of England. This research adds to the emerging paleopathological literature on PDB, while providing addi...
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
Brooks, John K. / Ghita, Ioana / Vallee, Evan M. / Charles-Marcel, Adrien L. / Price, Jeffery B.Page 478 - 485Excessive cementum formation, referred to as hypercementosis (HC), is an uncommon nonneoplastic process that principally occurs with permanent teeth. Widespread tooth involvement has been confined mostly to Paget disease of bone. Only a limited number of reports of HC coincident with periodontitis has appeared in the literature. The aim of this article is to present the clinical, radiographic, and histopathologic findings of a 44-year-old female with moderate to severe periodontitis synchronous with 22 HC-affected ...
Source: Quintessence International - Category: Dentistry Source Type: research
ConclusionsThe multi-analytical method employed suggests a diagnosis of monostotic form of FD. The diagnostic design incorporates multiple lines of evidence, including macroscopic, histopathological, and genetic analyses.SignificanceThrough the use of a multi-analytic approach, robust diagnoses can be offered. This case serves as one of the oldest examples of FD from an historical context. The genetic mutation detected, associated with FD, has not been previously reported in historical/ancient samples.
Source: International Journal of Paleopathology - Category: Pathology Source Type: research
ABSTRACTAn evidence ‐based clinical guideline for the diagnosis and management of Paget's disease of bone (PDB) was developed using GRADE methodology, by a Guideline Development Group (GDG) led by the Paget's Association (UK). A systematic review of diagnostic tests and pharmacological and nonpharmacological treatmen t options was conducted that sought to address several key questions of clinical relevance. Twelve recommendations and five conditional recommendations were made, but there was insufficient evidence to address eight of the questions posed. The following recommendations were identified as the most im portant:...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
We present an unusual radiographic series from a patient diagnosed with a low-grade Paget's osteosarcoma, a very rare and poorly described variant of the disease.
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
is a bone modelling disorder, characterized by skeletal deformity. Although the aetiology is largely unknown, environmental and genetic theories have been proposed. Serum alkaline phosphatase and plain radiographs remain the most commonly utilised investigations for diagnosis, and allow monitoring of the disease process. Second-generation bisphosphonates continue to be the mainstay of treatment, but surgical intervention may be required to treat complications including fracture, deformity and arthritis.
Source: Orthopaedics and Trauma - Category: Orthopaedics Authors: Tags: Principles of orthopaedics Source Type: research
Abstract Nuclear medicine studies evaluate physiology on a molecular level providing earlier detection of lesions before morphologic change is evident. 99mTc-MDP and 18F-fluoride bone scans detect osteomyelitis earlier than radiographs and computed tomography (CT); aid in diagnosis of temporomandibular joint disorder; and evaluate activity of condylar hyperplasia, extent of Paget disease, and viability of bone grafts. 18F-FDG PET/CT distinguish between soft tissue and bone infections and diagnose osteomyelitis complicated by fracture or surgery. FDG PET is more accurate than CT alone and has a major role in stagin...
Source: The Medical Clinics of North America - Category: General Medicine Authors: Tags: Dent Clin North Am Source Type: research
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