Osteoclastogenesis in Periodontal Diseases: Possible Mediators and Mechanisms

ConclusionIn this review, we summarize the mechanism of osteoclastogenesis accompanying periodontal diseases at the cellular level. We discuss a) the effects of LPS/TLR signaling and other cytokines on RANKL-dependent and -independent mechanisms involved in osteoclastogenesis; b) the recently identified role of several endogenous factors such as miRNA, IL-22, M1/M2 macrophages, and memory B cells in regulating osteoclastogenesis during periodontal pathogenesis.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research