Drug Approved for Rare Mutation in Gastrointestinal Tumor

The FDA has approved a tyrosine kinase inhibitor to treat adults with an unresectable or metastatic gastrointestinal stromal tumor (GIST) that has a specific genetic mutation.
Source: JAMA - Category: General Medicine Source Type: research

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This study aimed to explore the clinical efficacy and optimal duration of preoperative imatinib mesylate (IM...
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Volume 9, Issue 1, Dec 2020 .
Source: OncoImmunology - Category: Cancer & Oncology Authors: Source Type: research
We report a case of a 52-year-old male who presented with a huge abdominal lump arising from the right renal capsule that was found to be EGIST on histopathological examination and immunohistochemistry.
Source: Indian Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
AbstractPurposeWe aimed to compare the computed tomography (CT) imaging differences between gastric and intestinal gastrointestinal stromal tumors (GISTs).Materials and methodsThirty-eight patients with 38 gastric GISTs and 27 with 31 intestinal GISTs were enrolled. Tumors were classified as small (
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research
Publication date: Available online 1 April 2020Source: International Journal of Surgery Case ReportsAuthor(s): Ryosuke Arata, Hideki Nakahara, Takashi Urushihara, Toshiyuki Itamoto, Takashi Nishisaka
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Conclusions: Endoscopic resection for gastric SETs (
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - Category: Surgery Tags: Original Articles Source Type: research
This cohort substudy of a randomized clinical trial assesses the risk of death for patients with gastrointestinal stromal tumors with and without imatinib according to resection margin level using data from a randomized study on adjuvant imatinib.
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
Gastrointestinal stromal tumors (GISTs) are malignant tumors arising from interstitial cells of cajal that can be located in any part of the digestive system. Their most common sites are the stomach and small intestine. Surgery either upfront or after preoperative treatment with tyrosine kinase inhibitors (TKIs) is still the most important treatment modality in GIST. In this issue of JAMA Surgery, Gronchi et al evaluate the association of microscopic radicality with patient outcomes. They use long-term data from a randomized clinical trial in which patients received TKI for 2 years or no adjuvant treatment after surgery to...
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
AbstractPurposeThe aim of the study was to develop a patient-reported outcome measure for patients with sarcoma —the Sarcoma Assessment Measure (SAM).Methods and resultsThe systematic development of SAM included a three-stage, mixed-methods study using semi-structured interviews, focus groups and questionnaires, with all stages involving patients from across the United Kingdom. In-depth interviews were conducted with 121 patients (50% male; aged 13 –82; with soft tissue sarcoma (62%), bone tumours (28%) and gastrointestinal stromal tumours (10%)). Content analysis of the interview transcripts identified 1415 po...
Source: Quality of Life Research - Category: Health Management Source Type: research
Authors: Mustapar N, Zawawi MSF, Tuan Sharif SE Abstract BACKGROUND: Diagnosis of malignant peripheral nerve sheath tumor (MPNST) is rather challenging due to its divergent morphologic heterogeneity and lack of specific ancillary test. The emergence of H3K27 trimethylation (H3K27me3) as a new immunohistochemistry (IHC) marker for MPNST have recently available to assist pathologists in differentiating MPNST from other histologic mimics. We aim to study the expression pattern of H3K27me3 in MPNST and its histologic mimickers and their association with the clinicopathological data. METHODOLOGY: A total of 59 benig...
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
More News: Gastroenterology | Gastrointestinal Stromal Tumor (GIST) | General Medicine | Genetics