Effect of antenatal tetramethylpyrazine on lung development and YAP expression in rat model of experimental congenital diaphragmatic hernia.
Effect of antenatal tetramethylpyrazine on lung development and YAP expression in rat model of experimental congenital diaphragmatic hernia. Int J Clin Exp Pathol. 2020;13(1):81-88 Authors: Liao J, Liu W, Zhang L, Li Q, Hou F, Zou P Abstract The aim of this study was to investigate the therapeutic effects and underlying mechanism of tetramethylpyrazine (TMP) on lung development using a rat model of congenital diaphragmatic hernia (CDH). Nitrofen was used to induce CDH. Pregnant rats were divided into three groups: control, CDH, and CDH+TMP. In the CDH and CDH+TMP, fetuses only with left diaphragmatic hernias were chosen for analysis. Lung and body weight were recorded and lung histologic evaluations, image analysis, and western blot analysis of YAP, p-YAP and LATS1 were performed after lung processing. A markedly abnormal structure was observed, as evidenced by pulmonary hypoplasia and vascular remodeling, in the CHD. These abnormalities were improved in the CDH+TMP. There were significant differences between the CHD and CHD+TMP in percentage of medial wall thickness, arteriole muscularization, radial alveolar counts, AA%, and alveolar septal thickness. YAP expression was markedly increased in the CHD compared to the controls, which was not affected by antenatal TMP administration. However, prenatal TMP intervention significantly increased expression of LATS1 and phosphorylation of YAP in the CDH fetuses. Our results demonstrate that antenatal TMP admini...
Publication date: Available online 5 April 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Ayala Zilberman, Vered Eisenberg, Rakefet Yoeli, David Soriano, Eyal Sivan, Gil Golan, Roy Mashiach
Publication date: Available online 4 April 2020Source: Case Reports in Women's HealthAuthor(s): Peter Khamvongsa, Naiya Patel, Ayesha Aziz Ali, Nikita Bodoukhin, Octavio Carreno
As much of the world settles into a new routine of social distancing, couples are likely to have a lot more free time to snuggle at home together. But there could be a number of risks in trying to get pregnant right now.
In this study, we aimed to assess the possible association between affective temperaments and GH.Methods: This cross-sectional study was conducted on women with GH hospitalized in hospitals affiliated with Mashhad University of Medical Sciences, compared with healthy women admitted for normal delivery in the same centers during the study. Data were collected via Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto-questionnaire (TEMPS-A) and Depression Anxiety Stress Scale (DASS) 21.Results: TEMPS-A revealed that scores anxious (P
Conclusion: This study provides evidence for blood pressure management in Chinese pregnant women. PMID: 32243195 [PubMed - as supplied by publisher]
CONCLUSIONS: Transabdominal laparoscopic approach is a safe and feasible approach to all cases of symptomatic hiatus and diaphragmatic hernia. PMID: 30322286 [PubMed - as supplied by publisher]
CONCLUSIONS: These findings indicate that non-uniform lung hypoplasia caused by DH alters the distribution of ventilation away from hypoplastic and into normally grown lung regions. During transition, the increase in PBF and pulmonary venous return, which is vital for maintaining cardiac output, is not affected by lung hypoplasia.Pediatric Research accepted article preview online, 11 April 2017. doi:10.1038/pr.2017.91. PMID: 28399114 [PubMed - as supplied by publisher]
Norman Oneil MachadoNorth American Journal of Medical Sciences 2016 8(2):65-74Bochdalek hernia (BH) is an uncommon form of diaphragmatic hernia. The rarity of this hernia and its nonspecific presentation leads to delay in the diagnosis, with the potential risk of complications. This review summarizes the relevant aspects of its presentation and management, based on the present evidence in the literature. A literature search was performed on PubMed, Google Scholar, and EMBASE for articles in English on BH in adults. All case reports and series from the period after 1955 till January 2015 were included. A total of 180 articl...
CONCLUSIONS: Healthcare providers will occasionally encounter foetal anomalies which may require surgery while performing prenatal screening. They may need to provide early counselling to expectant parents to inform their expectations. When indicated, referrals should be made to a foetal care centre for prenatal consultation. For conditions which may cause danger or distress to the foetus in the immediate postnatal period, preparations should be made to ensure sufficient resources are available at the location of birth. PMID: 26321230 [PubMed - as supplied by publisher]
We present the successful utilization of this product in two cases which were at extremely high risk for future recurrence. Additional investigations should be done and long term follow up regarding application of this product for this challenging clinical condition.