Drug recrystallization in drug-in-adhesive transdermal delivery system: A case study of deteriorating the mechanical and rheological characteristics of testosterone TDS

In conclusion, this study demonstrated that the extent of drug recrystallization can be quantitatively correlated with the deterioration of performance characteristics of TDS products.Graphical abstractEffect of drug crystallization in TDS on peel adhesion (A); rheology of the adhesive matrix (B); and drug permeation through human cadaver skin samples (C). In Figure B, the relative standard deviations did not exceed 5% of the plotted yield stress values.
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research