Synthesis, crystal structure, bovine serum albumin binding studies of 1,2,4-triazine based copper(I) complexes

Publication date: Available online 31 January 2020Source: Journal of Molecular StructureAuthor(s): Larica Pathaw, Themmila Khamrang, Arunkumar Kathiravan, Marappan VelusamyAbstractA series of new copper complexes have been synthesized and completely characterized by pivotal analytical techniques. The coordination geometry around copper(I) complex was best described as distorted tetrahedral geometry. The binding of bovine serum albumin with Cu(I) complexes are also been investigated. The Stern–Volmer analysis on quenching data exhibits the presence of the static quenching mechanism. The binding constants were calculated using modified Stern-Volmer, Lineweaver–Burk and Scatchard plots. All the complexes exhibit the binding constants in the order of 104. Thus, these results can contribute to the development of Cu(I) based drugs.
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research