An effective method for the determination of the enantio-purity of L-α-glycerophosphocholine (L-α-GPC)

Publication date: Available online 8 February 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Lorenzo de Ferra, Antonio Massa, Antonia Di Mola, Bernd DiehlAbstractHerein we describe for the first time a practical analytical method for determining the enantio-purity of L-α-glycerophosphocholine (L-α-GPC) by chiral derivatization. The use of a suitable chiral boronic acid allowed the formation of a mixture of two diastereomeric boronate esters whose ratio, carefully analyzed by 1HNMR spectroscopy, reflects L-α-GPC enantiomeric excesses. The determination of the enantiopurity of L-α-GPC furnishes convincing correlations with its manufacturing process.Graphical abstract
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research