Variability in Diagnosed Asthma in Young Children in a Large Pediatric Primary Care Network

Publication date: Available online 7 February 2020Source: Academic PediatricsAuthor(s): Chén C. Kenyon, Mitchell G. Maltenfort, Rebecca A. Hubbard, Leah H. Schinasi, Anneclaire J. De Roos, Sarah E. Henrickson, Tyra C. Bryant-Stephens, Christopher B. ForrestAbstractObjectivesOur objectives were to (1) quantify the frequency of wheezing episodes and asthma diagnosis in young children in a large pediatric primary care network and (2) assess the variability in practice-level asthma diagnosis, accounting for common asthma risk factors and comorbidities. We hypothesized that significant variability in practice-level asthma diagnosis rates would remain after adjusting for associated predictors.MethodsWe generated a retrospective longitudinal birth cohort of children who visited one of 31 pediatric primary care practices within the first 6 months of life from 1/2005-12/2016. Children were observed for up to 8 years or until the end of the observation window. We used multivariable discrete time survival models to evaluate predictors of asthma diagnosis by 3-month age intervals. We compared unadjusted and adjusted proportions of children diagnosed with asthma by practice.ResultsOf the 161,502 children in the cohort, 34,578 children (21%) received at least one asthma diagnosis. In multivariable modeling, male gender, minority race/ethnicity, gestational age
Source: Academic Pediatrics - Category: Pediatrics Source Type: research

Related Links:

Authors: Nowicki RJ, Trzeciak M, Kaczmarski M, Wilkowska A, Czarnecka-Operacz M, Kowalewski C, Rudnicka L, Kulus M, Mastalerz-Migas A, Peregud-Pogorzelski J, Sokołowska-Wojdyło M, Śpiewak R, Adamski Z, Czuwara J, Kapińska-Mrowiecka M, Kaszuba A, Krasowska D, Krêcisz B, Narbutt J, Majewski S, Reich A, Samochocki Z, Szepietowski J, Woźniak K Abstract Atopic dermatitis is a chronic and recurrent inflammatory dermatosis with concomitant intensive pruritus, and is diagnosed both in children and adults. Atopic dermatitis-patients are predisposed to have bacterial, viral and fungal skin infections; they also su...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
CONCLUSION: PROTIA™ Specific IgG4® showed high consistency with ImmunoCAP® in measuring sIgG4. This assay is applicable to various clinical fields, including allergen immunotherapy and food allergy. PMID: 32469176 [PubMed - in process]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
AbstractWhile activation of immune system may lead to a lower risk of some diseases, it has been shown that a history of atopic allergic disorders such as asthma, hay fever, eczema, and food allergies could be related to several types of cancer. However, the evidence is not entirely conclusive. Two proposals suggest a possible mechanism for the association between allergic disorders and cancers: immune surveillance and the antigenic stimulation. The association of allergy and cancer may vary by cancer site and the type of exposure. The aim of current review was to summarize the current knowledge of the association between ...
Source: IUBMB Life - Category: Research Authors: Tags: CRITICAL REVIEW Source Type: research
The incidence of allergic diseases has increased over the last two decades.1 The study of the origins of allergy is an important topic, both to understand the mechanisms of allergy development and to produce interventions to treat or prevent allergic diseases. The term atopic march is used to describe the progression of allergic disease development, beginning with atopic dermatitis (AD) and progressing to food allergy (FA), asthma, and allergic rhinitis (AR). While it is necessary to focus on early childhood factors, the prenatal environment must also be considered.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Perspective Source Type: research
Growing evidence shows that atopic dermatitis (AD), food allergy (FA), allergic rhinitis, and asthma are largely determined during the first 1000  days (time elapsed from conception to the 2nd birthday). The AR...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Study protocol Source Type: research
Abstract Atopic dermatitis (AD) is the most common inflammatory skin condition in pediatric patients. AD has long been associated with comorbidities including food allergies, asthma, and allergic rhinitis, but recent literature has expanded this list to include attention-deficit/hyperactivity disorder and depression. AD has tremendous impact on quality of life for both affected children and their families. Improved understanding of AD pathogenesis, particularly regarding skin barrier dysfunction, the role of the cutaneous microbiome, and immune dysregulation, has spawned exciting new therapeutic directions. Althou...
Source: Pediatric Annals - Category: Pediatrics Authors: Tags: Pediatr Ann Source Type: research
This study aimed to determine serum total IgE level, eosinophil count, and serum level of IFN-γ, in relation to the age of atopic patients and genotyping of the IFN-γ gene at +874 T/A in relation to serum IFN-γ level. As well as comparing of IFN-γ concentrations of atopic patients according to genotypes in atopic patients and apparently healthy control. The studied groups were 25 apparently healthy controls and 75 atopic patients (25 asthma patients, 25 allergic rhinitis patients and 25 atopic dermatitis patients). The obtained results showed that, the prevalence of atopic diseases occurred in the...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Type I allergic hypersensitivity disorders (atopy) including asthma, atopic dermatitis, allergic rhinitis, and food allergy are on the rise in developed and developing countries. Engineered nanomaterials (ENMs) span a large spectrum of material compositions including carbonic, metals, polymers, lipid-based, proteins, and peptides and are being utilized in a wide range of industries including healthcare and pharmaceuticals, electronics, construction, and food industry, and yet, regulations for the use of ENMs in consumer products are largely lacking. Prior evidence has demonstrated the potential of ENMs to induce and/or agg...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 7 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Helen T. Wang, Christopher M. Warren, Ruchi S. Gupta, Carla DavisAbstractBackgroundShellfish allergy (SA) is one of the most common food allergies causing anaphylaxis in adults and children. There is limited data showing the prevalence of SA in US children.ObjectiveTo determine the prevalence and reaction characteristics of SA in the US pediatric population.MethodsA cross-sectional food allergy prevalence survey was administered via phone and web by the National Opinion Research Center at the Unive...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
The prevalence of allergic diseases and asthma has been on the rise in developed countries for the past 50 years, likely associated with changes in living conditions that have inhibited certain early-life microbial exposures normally instrumental in the development of the infant immune system. Consistent with this, a large body of data to date suggests that living on farms is associated with a major reduction in the risk of asthma and atopic diseases such as allergic rhinitis, including studies from Europe1,2 and North America among the Indiana Amish3,4.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
More News: Academia | Allergy | Allergy & Immunology | Asthma | Children | Food Allergy | Hay Fever | Pediatrics | Primary Care | Primary Care Practices