Optical Vaginal Biopsy Using Optical Coherence Tomography

In this study, we sought to compare vaginal tomographic images of premenopausal, perimenopausal, and postmenopausal women, demonstrate feasibility of tracking vaginal tissue changes after treatment with fractional-pixel CO2 laser therapy, and obtain a histologic correlation of these findings. Methods Enrolled subjects underwent imaging and were divided into 3 groups based on menopausal status. Women with genitourinary syndrome of menopause who received fractional-pixel CO2 laser therapy were assessed before and after treatment. A cadaveric vagina was used to obtain tomographic and histologic images to assess for accuracy. Our primary outcome was mean vaginal epithelial thickness. Statistical analysis was performed using analysis of variance and t tests, respectively. Results Among 6 women, the mean vaginal epithelial thickness decreased with menopause (P
Source: Female Pelvic Medicine and Reconstructive Surgery - Category: OBGYN Tags: AUGS Special Issue Submissions Source Type: research