Plasma osteoprotegerin as a biomarker of poor glycaemic control that predicts progression of albuminuria in type 2 diabetes mellitus: A 3-year longitudinal cohort study

Compelling evidence suggests that poorly-controlled hyperglycaemia in early diabetes leads to ‘metabolic memory’ (also known as ‘legacy effect’) that predisposes individuals to increased risk of micro- and macrovascular complications [1,2]. These complications often resist amelioration by treatment intensification at a later disease stage, thus resulting in significant morbidity and mortality in the long term [1,2]. Therefore, it is critical to implement early intensive glycaemic control to achieve durable good glycaemic control.

Source: Diabetes Research and Clinical Practice - February 3, 2020 Category: Endocrinology Authors: Angela Mei Chung Moh, Sharon Li Ting Pek, Jianjun Liu, Jiexun Wang, Tavintharan Subramaniam, Keven Ang, Chee Fang Sum, Pek Yee Kwan, Simon Biing Ming Lee, Wern Ee Tang, Su Chi Lim Source Type: research