Work participation and sick leave in women with systemic lupus erythematosus and matched controls during and after pregnancy.

Work participation and sick leave in women with systemic lupus erythematosus and matched controls during and after pregnancy. Clin Exp Rheumatol. 2020 Jan 28; Authors: Blomjous BS, Ter Wee MM, Abheiden CNH, Voskuyl AE, de Vries JIP, Bultink IEM PMID: 31994480 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

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Abstract Current research in the field of systemic lupus erythematosus (SLE) and pregnancy focuses on predictors of adverse pregnancy outcomes, the safety and efficacy of hydroxychloroquine (HCQ) in pregnancy and the importance of preconception counselling. In particular, the prospective predictors of pregnancy outcome: biomarkers in antiphospholipid antibody syndrome and SLE (PROMISSE) study adds to the understanding of risk factors for adverse outcomes. There is increasing evidence of the numerous benefits associated with continuing HCQ treatment in pregnancy and for the use of low-dose acetylsalicylic acid in t...
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
CONCLUSION: The updated recommendations on AM treatment in rheumatology in particular include a more rigorous measuring of doses, risk stratification in monitoring and defined ophthalmological examination methods to detect a possible retinopathy. PMID: 32236844 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
AbstractIntroductionSeveral factors have been associated with the development of preeclampsia in women with systemic lupus erythematosus (SLE).ObjectiveTo identify risk factors associated with preeclampsia in patients with SLE and its impact on fetal outcomes.Patients and methodsWe studied a prospective cohort of pregnancies in women with SLE from January 2009 to December 2018. Demographic, clinical, serological and drug use characteristics were compared between patients who developed preeclampsia and those who did not, as well as the main neonatal outcomes. An adjusted logistic regression analysis was performed to identif...
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
This study aimed to evaluate the factors associated with pregnancy outcomes in patient...
Source: BMC Research Notes - Category: Research Authors: Tags: Research note Source Type: research
Abstract It has been known for many years that there are risks associated with pregnancy for women with a range of established connective tissue diseases (CTD), especially systemic lupus erythematosus (SLE). These risks can be to do with the disease itself, the autoantibodies found in association with the disease, or the medications used to treat symptoms. This recent large, epidemiological study from the UK looks closely at this issue from a different perspective (BJOG 2020 xxxx). Using a retrospective case-control design, the authors examine the risks for women who experienced an adverse pregnancy outcome (APO) ...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
AbstractThe dysregulation of the JAK –STAT pathway is associated with various immune disorders. Four JAK inhibitors have been approved for rheumatoid arthritis (RA), and numerous JAK inhibitors are currently being tested in phase II and III trials for the treatment of various autoimmune inflammatory diseases. In this narrative review , we elucidate the involvement of the JAK–STAT signaling pathway in the pathogenesis of connective tissue diseases (CTDs). We also discuss the efficacy of the first- and second-generation JAK inhibitors (tofacitinib, baricitinib, ruxolitinib, peficitinib, filgotinib, upadacitinib, ...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Many people think of hair loss as a male problem, but it also affects at least a third of women. But unlike men, women typically experience thinning hair without going bald, and there can be a number of different underlying causes for the problem. “Some are associated with inflammation in the body. Some are female-pattern hair loss,” says Dr. Deborah Scott, assistant professor of dermatology at Harvard Medical School and co-director of the Hair Loss Clinic at Brigham and Women’s Hospital. But the good news is that in many cases this hair loss can be stabilized with treatment, and it may be reversible. Whe...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Skin and Hair Care Women's Health Source Type: blogs
Lupus patients are at risk for pregnancy loss, and it has been generally accepted that women with SLE should have low disease activity prior to conception. However, there are conflicting results regarding the ...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
Abstract OBJECTIVES: We assessed the incidence, risk factors and adverse birth outcomes associated with elevated liver enzymes and low platelets (HELLP) syndrome. DESIGN: A retrospective population-based cohort study. SETTING: Canada (excluding Quebec), 2012/13-2015/16. POPULATION: Mothers with a singleton hospital live birth or stillbirth at ≥24 weeks gestation (N=1,078,323). METHODS: HELLP syndrome was identified using ICD-10-CA diagnostic code from delivery hospitalization data. We used logistic regression to identify independent risk factors for HELLP syndrome by obtaining adjusted ...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
Publication date: April 2020Source: American Journal of Kidney Diseases, Volume 75, Issue 4Author(s):
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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