Binding of adenosine derivatives to carrier proteins may reduce their antiplatelet activity.

In conclusion, HSA and lipoproteins are important carriers for ARagonists, which can affect pharmacodynamics of ARagonists used as platelet inhibitors.
PMID: 31987853 [PubMed - as supplied by publisher]

Source: Biochemical Pharmacology - January 23, 2020 Category: Drugs & Pharmacology Authors: Wzorek J, Bednarek R, Watala C, Boncler M Tags: Biochem Pharmacol Source Type: research