The world of asRNAs in Gram-negative and Gram-positive bacteria

Publication date: Available online 11 January 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Maxence Lejars, Eliane HajnsdorfAbstractBacteria exhibit an amazing diversity of mechanisms controlling gene expression to both maintain essential functions and modulate accessory functions in response to environmental cues. Over the years, it has become clear that bacterial regulation of gene expression is still far from fully understood. This review focuses on antisense RNAs (asRNAs), a class of RNA regulators defined by their location in cis and their perfect complementarity with their targets, as opposed to small RNAs (sRNAs) which act in trans with only short regions of complementarity. For a long time, only few functional asRNAs in bacteria were known and were almost exclusively found on mobile genetic elements (MGEs), thus, their importance among the other regulators was underestimated. However, the extensive application of transcriptomic approaches has revealed the ubiquity of asRNAs in bacteria. This review aims to present the landscape of studied asRNAs in bacteria by comparing 67 characterized asRNAs from both Gram-positive and Gram-negative bacteria. First we describe the inherent ambiguity in the existence of asRNAs in bacteria, second, we highlight their diversity and their involvement in all aspects of bacterial life. Finally we compare their location and potential mode of action toward their target between Gram-negative and Gram-...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - Category: Genetics & Stem Cells Source Type: research

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CONCLUSION: The underlying cause of hip pain in children should be diagnosed early to avoid adverse sequelae. PMID: 32070474 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Authors: Zalloum N, Trappe HJ PMID: 32070473 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Authors: Kohler B, Kellerer C, Schultz K, Wittmann M, Atmann O, Linde K, Hapfelmeier A, Schneider A Abstract BACKGROUND: Asthma education (AE) is associated with reduced hospitalization and disability. We compared the effectiveness of an electronic AE program (eAEP) with a conventional face-to-face AE program (presence-based AEP; pAEP) for asthma knowledge (AK) with regard to self-management. METHODS: A randomized controlled pilot study was conducted in a pulmonary reha- bilitation clinic. AK was determined by means of the Asthma Knowledge Test (AKT). The change in AKT score within each group was calculated wit...
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Authors: Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P PMID: 32070471 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
CONCLUSIONS: Variables significantly predictive of MetS were age, male gender, African-American ethnicity, BMI, and lycopene intake. PMID: 32067763 [PubMed - as supplied by publisher]
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
Authors: Richmond J, Mbah OM, Dard SZ, Jordan LC, Cools KS, Samuel CA, Khan JM, Manning MA Abstract BACKGROUND: Lung cancer is the leading cause of cancer death in the US, and significant racial disparities exist in lung cancer outcomes. For example, Black men experience higher lung cancer incidence and mortality rates than their White counterparts. New screening recommendations for low-dose computed tomography (LDCT) promote earlier detection of lung cancer in at-risk populations and can potentially help mitigate racial disparities in lung cancer mortality if administered equitably. Yet, little is known about the ...
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
Publication date: February 2020Source: Neurophysiologie Clinique, Volume 50, Issue 1Author(s):
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Publication date: Available online 20 February 2020Source: Neuroscience ResearchAuthor(s): Yan Zheng, Kazuyuki Kanosue, Tetsuro MuraokaAbstractIn bimanual cyclical continuous movements, the relative timing of the most salient movement phase in each movement is a predominant constraint. This is the case for coordination when both movements have a single most salient phase (the relative-salience hypothesis). We tested whether the relative-salience hypothesis could explain results obtained for repetitive discrete movements, utilizing finger tapping. In experiment 1, participants performed unimanual alternate two-finger tappin...
Source: Neuroscience Research - Category: Neuroscience Source Type: research
Publication date: Available online 20 February 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Melike M. Fourie, Ruud Hortensius, Jean DecetyAbstractForgiveness―a shift in motivation away from retaliation and avoidance towards increased goodwill for the perceived wrongdoer―is vital for restoring social relationships and positively impacts personal wellbeing and society at large. Parsing the psychological and neurobiological mechanisms of forgiveness remains an outstanding challenge (not least because of conceptual and methodological difficulties in the field), but contributes theoretical clarity. Here, we...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Publication date: 19 February 2020Source: Neuron, Volume 105, Issue 4Author(s): Silvestro Micera, Matteo Caleo, Carmelo Chisari, Friedhelm C. Hummel, Alessandra PedrocchiStroke is one of the leading causes of long-term disability. Advanced technological solutions (“neurotechnologies”) exploiting robotic systems and electrodes that stimulate the nervous system can increase the efficacy of stroke rehabilitation. Recent studies on these approaches have shown promising results. However, a paradigm shift in the development of new approaches must be made to significantly improve the clinical outcomes of neurotechnolo...
Source: Neuron - Category: Neuroscience Source Type: research
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