Computer-Aided Histopathological Image Analysis Techniques for Automated Nuclear Atypia Scoring of Breast Cancer: a Review

AbstractBreast cancer is the most common type of malignancy diagnosed in women. Through early detection and diagnosis, there is a great chance of recovery and thereby reduce the mortality rate. Many preliminary tests like non-invasive radiological diagnosis using ultrasound, mammography, and MRI are widely used for the diagnosis of breast cancer. However, histopathological analysis of breast biopsy specimen is inevitable and is considered to be the golden standard for the affirmation of cancer. With the advancements in the digital computing capabilities, memory capacity, and imaging modalities, the development of computer-aided powerful analytical techniques for histopathological data has increased dramatically. These automated techniques help to alleviate the laborious work of the pathologist and to improve the reproducibility and reliability of the interpretation. This paper reviews and summarizes digital image computational algorithms applied on histopathological breast cancer images for nuclear atypia scoring and explores the future possibilities. The algorithms for nuclear pleomorphism scoring of breast cancer can be widely grouped into two categories: handcrafted feature-based and learned feature-based. Handcrafted feature-based algorithms mainly include the computational steps like pre-processing the images, segmenting the nuclei, extracting unique features, feature selection, and machine learning –based classification. However, most of the recent algorithms are ...
Source: Journal of Digital Imaging - Category: Radiology Source Type: research

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A 60-year-old woman with no known family history of breast cancer and an unremarkable medical history presented to her primary care physician after self-palpating a mass in her left breast. A mammogram and ultrasound demonstrated a 3.5 × 3.4-cm mass at 7 o’clock, 5 cm from the nipple in her left breast. A biopsy showed infiltrating, moderately differentiated mammary carcinoma with ductal and lobular features. Estrogen and progesterone receptors stained positive, human epidermal growth factor receptor-2 was negative by immunohis tochemistry, and Ki67 was>50%.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
We present a rare case of Paget disease of the nipple without the typical characteristics, detected by simple nipple scraping technique. A 62-year-old woman presented with a small fissure on the left nipple with scant clear nippledischarge. There were no other changes to the nipple-areola complex. The mammography and ultrasound were unremarkable. However, nipplescraping provided the immediate cytological diagnosis of Paget disease. Breast MRI with core biopsy showed high grade ductal carcinoma in situwith suggestion of microinvasion, confirmed histologically after mastectomy. Nipple scraping is a simple and inexpensive tec...
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
AbstractBackgroundBreast density is an independent risk factor for breast cancer. Mammography is supplemented with handheld ultrasound (HHUS) to increase sensitivity. Automatic breast ultrasound (ABUS) is an alternative to HHUS. Our study wanted to assess the difference in execution and reading time between ABUS and HHUS.Methods and materialsN = 221 women were evaluated consecutively between January 2019 and June 2019 (average age 53 years; range 24–89). The execution and reading time of ABUS and HHUS was calculated with an available stopwatch. Time started for both procedures when the patient was ...
Source: La Radiologia Medica - Category: Radiology Source Type: research
Abstract A 54-year-old woman on methotrexate (MTX) treatment developed reddish skin change in her right breast. Mammography and ultrasound showed no masses in the breasts but bilateral mammary glands presented diffuse lower-level echoes. Only 19 days later, the patient developed bilateral breast masses. Histological examination showed that diffuse large B-cell lymphoma cells spread widely and sparsely in the bilateral breasts in addition to the tumor cell conglomerate, leading to the diagnosis of MTX-associated lympho-proliferative disorders (MTX-LPDs). Withdrawal of MTX resulted in complete disappearance of ...
Source: Breast Cancer - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research
Like everyone, I assume I’ll live forever. Although I often wonder whether anyone would come to my funeral and who would wear black, it never actually occurrs to me that there is an endpoint. It’s almost as if I would come along too to watch proceedings running smoothly and along the lines I wanted. Death was something I thought about, but in a rather abstract, offhand sort of way. It happened, of course I knew I would die at some point, but that point was somewhere out there … way off from here, where I am now. And then I hit a brick wall. The wall consisted of a tiny little bit of blood coughed up in s...
Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Emotional Health Happiness Thought for the day Women's Health my story Source Type: news
Jacinta E. Browne The aim of this work was to develop multimodal anthropomorphic breast phantoms suitable for evaluating the imaging performance of a recently-introduced Microwave Imaging (MWI) technique in comparison to the established diagnostic imaging modalities of Magnetic Resonance Imaging (MRI), Ultrasound (US), mammography and Computed Tomography (CT). MWI is an emerging technique with significant potential to supplement established imaging techniques to improve diagnostic confidence for breast cancer detection. To date, numerical simulations have been used to assess the different MWI scanning and image recon...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
This article focuses on reviewing the background of microwave techniques for breast tumour detection. In particular, this study reviews the recent advancements in active microwave imaging, namely microwave tomography and radar-based techniques. The main objective of this paper is to provide researchers and physicians with an overview of the principles, techniques, and fundamental challenges associated with microwave imaging for breast cancer detection. Furthermore, this study aims to shed light on the fact that until today, there are very few commercially available and cost-effective microwave-based systems for breast canc...
Source: Sensors - Category: Biotechnology Authors: Tags: Review Source Type: research
Eight recommendations released for imaging women post-mastectomy and breast reconstruction.
Source: Diagnostic Imaging - Category: Radiology Authors: Tags: Breast Health Ultrasound Breast Imaging Mammography Screening Tomosynthesis Source Type: news
Abstract Detection of breast cancer has particular importance for the diagnosis of cancer diseases. This is the most common type of cancer among women. Breast cancer is a malignant tumor of the glandular tissue of the breast. It is proposed to use infrared spectroscopy of blood serum as a simple and quick way to detect breast cancer. The paper presents the results of research using the methods of multivariate processing of IR spectra of human blood serum obtained by ATR-FTIR spectroscopy. The paper presents the results of research using the methods of multivariate processing of IR spectra of human blood serum obta...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
AbstractIntroductionBreast cancer is the most commonly diagnosed female cancer. Diagnosis in younger women (under 35  years) is different to their older counterparts, and mammography is not considered as sensitive in this cohort. Consequentially, younger patients may present later with more advanced disease.MethodsThis is a retrospective analysis of a prospectively updated database containing consecutive patients who presented to the symptomatic breast unit of Galway University Hospital between 2009 and 2015. Patient clinicopathologic factors, clinical examination features, diagnostic radiological modalities and Bi-RA...
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
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