The retinoid derivant ECPIRM selectively exhibited anti-proliferation effects in Cutaneous T-Cell Lymphoma via ITK-mediated signaling pathway

Cutaneous T-cell lymphoma (CTCL) was a highly heterogeneous non-Hodgkin lymphomas characterized by the residing of malignant T lymphocytes in the lesions of skin [1]. The incidence of CTCL was 6.4 per million, which made it the second most common extra-nodal non-Hodgkin lymphomas [2]. Mycosis fungoides (MF) and S ézary syndrome (SS) were the most common form of CTCL, both of them accounted for more than 80% of CTCL, and MF was the main form of CTCL [2–4]. Owning to the heterogeneity and the scarcity of special targets, the precise treatment of CTCL also met huge challenges.

Source: Journal of Dermatological Science - January 23, 2020 Category: Dermatology Authors: Hongyang Li, Cheng Wang, Pengcheng Ma, Mengli Zhang, Hua Yang, Shengtao Yuan, Jun Wei, Lei Tao, Kun Qian, Man Xu, Lingjun Li Source Type: research