Corrigendum to “FANCA knockout in human embryonic stem cells causes a severe growth disadvantage” Stem Cell Res.13/2 (2014) 240-50

Publication date: Available online 23 January 2020Source: Stem Cell ResearchAuthor(s): Kim Vanuytsel, Qing Cai, Satish Khurana, Swati Shetty, Joris R. Vermeesch, Laura Ordovas, Catherine M. Verfaillie
Source: Stem Cell Research - Category: Stem Cells Source Type: research

Related Links:

Publication date: July 2020Source: Materials Science and Engineering: C, Volume 112Author(s): Yuquan Li, Tongmeng Jiang, Li Zheng, Jinmin Zhao
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study, we analyzed the DNA sequences of the region and identified a motif for polycomb repressive complex 2 (PRC2). Chromatin immunoprecipitation assay indicates the binding of the PRC2 component, SUZ12, to the motif. A mutation in the motif decreased DNA methylation in embryonic stem cells and increased Robo4 promoter activity in endothelial cells. An inhibitor for the PRC2 component, EZH2, induced the promoter activity and expression of Robo4 in endothelial cells treated with or without TNFα. Taken together, these results indicate that the PRC2 components maintain DNA hypermethylation and suppress Robo4 exp...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
Abstract Sema3C has been reported to promote glioma stem cells self-renewal and glioblastoma growth. However, the prognostic value and the regulatory mechanism for its abnormal expression in glioma remain poorly understood. In the current study, the immunohistochemistry results demonstrated that Sema3C was overexpressed in 169 of 216 (78.2%) interpretable glioma patients compared with 3 of 15 (20.0%) interpretable non-neoplastic brain cases (p = 0.0001). Sema3C overexpression was significantly associated with histologic type (p = 0.008), high Ki67 labeling index (p = 0.02)...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
Abstract Liver transplantation and hepatocyte transplantation are effective treatments for severe liver injuries, but the donor shortage is a serious problem. Therefore, hepatocyte-like cells generated from human induced pluripotent stem (iPS) cells with unlimited proliferative ability are expected to be a promising new transplantation resource. The technology for hepatic differentiation from human iPS cells has made great progress in this decade. The efficiency of hepatic differentiation now exceeds 90%, making it possible to produce nearly homogeneous hepatocyte-like cells from human iPS cells. Because there is ...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
This study investigated the effect of differentiation on the expression of two immune checkpoint inhibitors, human leukocyte antigen‑G (HLA‑G) and programmed death ligand‑1 (PD‑L1). Two cancer cell lines (OVCAR‑3‑NIH and KATO‑III) were treated with adipocyte and neurocyte differentiation media for 14 days. Bone‑marrow derived mesenchymal stem cells (BM‑MSCs) were used as control healthy stem cells. We found that the cancer cell lines (OVCAR‑3‑NIH and KATO‑III) when subjected to differentiation lost their proliferation ability. BM‑MSC proliferation was not halted but was decreased in the adipo...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Inhibitory effect of therapeutic genes, cytosine deaminase and interferon‑β, delivered by genetically engineered stem cells against renal cell carcinoma. Oncol Rep. 2020 Mar 30;: Authors: Kim GS, Kim SM, Kim SU, Lee G, Choi KC Abstract Although the effects of stem cells expressing anticancer genes on tumor growth have been demonstrated by many researchers in various types of cancer, relatively few studies have investigated their inhibitory effects on cancer metastasis. In the present study, we examined the inhibitory effects of cytosine deaminase (CD)/5‑fluorocytosine (5‑FC) and interferon...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Publication date: Available online 2 April 2020Source: Stem Cell ReportsAuthor(s): Nina Maenhoudt, Charlotte Defraye, Matteo Boretto, Ziga Jan, Ruben Heremans, Bram Boeckx, Florian Hermans, Ingrid Arijs, Benoit Cox, Els Van Nieuwenhuysen, Ignace Vergote, Anne-Sophie Van Rompuy, Diether Lambrechts, Dirk Timmerman, Hugo Vankelecom
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 2 April 2020Source: Stem Cell ReportsAuthor(s): Max Friesen, Curtis R. Warren, Haojie Yu, Takafumi Toyohara, Qiurong Ding, Mary H.C. Florido, Carolyn Sayre, Benjamin D. Pope, Loyal A. Goff, John L. Rinn, Chad A. Cowan
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 2 April 2020Source: Stem Cell ReportsAuthor(s): Amaleah A. Hartman, S. Maxwell Scalf, Jian Zhang, Xiao Hu, Xinyue Chen, Anna E. Eastman, Cindy Yang, Shangqin Guo
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 2 April 2020Source: Stem Cell ReportsAuthor(s): Jeffrey M. Bernitz, Katrina Rapp, Michael G. Daniel, Dmitrii Shcherbinin, Ye Yuan, Andreia Gomes, Avinash Waghray, Ran Brosh, Alexander Lachmann, Avi Ma'ayan, Dmitri Papatsenko, Kateri A. Moore
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
More News: Stem Cell Therapy | Stem Cells