Eighteen months of combined Mediterranean diet and high-intensity interval training successfully maintained body mass loss in obese individuals

Publication date: Available online 22 January 2020Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Maxime Boidin, Anil Nigam, Valérie Guilbeault, Elise Latour, Antoine Langeard, Martin Juneau, Mathieu Gayda
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research

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Conclusions: Adipose expression of TBX1 is necessary, but not sufficient, to defend body temperature during cold via proper UCP1 expression. Adipose TBX1 expression was also required for proper insulin signaling in subcutaneous adipose as well as maintaining β-adrenergic sensitivity but overexpression of TBX1 was not sufficient to induce adipocyte beiging or prevent diet induced obesity. TBX1 expression is enriched in adipose stem cells in which it has contrasting effects on adipogenesis in mouse versus human cells. Collectively, these data demonstrate the importance of adipose TBX1 in the regulation of beige adipocyt...
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
ConclusionsPPARγ and PPARα synergize to induce robust browning of white fat in vivo, via PPARγ activation in adipose, and PPARα-mediated increase in FGF21.Graphical abstractDual PPARα/γ activation is superior to selective PPARγ activation at inducing browning of white fat in vivo: via PPARγ action in the adipose and a PPARα-mediated action in the liver resulting in increased circulating fibroblast growth factor 21 (FGF21).
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Authors: Rangaswamy D, Guddattu V, Webster AC, Borlace M, Boudville N, Clayton P, Badve S, Johnson DW, Sud K Abstract BACKGROUND: Icodextrin is a high molecular weight, starch-derived glucose polymer that is used as an osmotic agent in peritoneal dialysis (PD) to promote ultrafiltration. There has been wide variation in its use across Australia and the rest of the world, but it is unclear whether these differences are due to patient- or centre-related factors. METHODS: Using the Australia and New Zealand Dialysis and Transplant Registry, all adult patients (>18 years) who started PD in Australia between 1 Ja...
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
We examined whether this effect was maintained at 12-months post-intervention. We followed up CODEX trial participants at 12-months post trial endpoint, collecting information on weight, BMI, waist circumference, blood pressure, fasting glucose, HbA1c, and use of metformin. The primary outcome of interest was change in weight from trial baseline to 12-months post endpoint and trial endpoint to 12-months post endpoint compared between former exenatide and usual care participants. Only HbA1c differed between baseline and 12-months post endpoint between the exenatide and control groups. From endpoint to 12-month follow up the...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: 18 February 2020Source: Cell Reports, Volume 30, Issue 7Author(s): Helen M. Melo, Gisele da S. Seixas da Silva, Marcella Ramos Sant’Ana, Camila Vieira Ligo Teixeira, Julia R. Clarke, Vivian S. Miya Coreixas, Bruno C. de Melo, Juliana T.S. Fortuna, Leticia Forny-Germano, José Henrique Ledo, Maíra S. Oliveira, Claudia P. Figueiredo, Raphaelle Pardossi-Piquard, Frédéric Checler, José María Delgado-García, Agnès Gruart, Licio A. Velloso, Marcio L.F. Balthazar, Dennys E. Cintra, Sergio T. FerreiraSummaryObesity has been associated with cognitive dec...
Source: Cell Reports - Category: Cytology Source Type: research
Women who were obese before pregnancy were approximately twice as likely to report that their child had ADHD or symptoms of hyperactivity.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news
Authors: El Sherif O, Dhaliwal A, Newsome PN, Armstrong M Abstract Introduction: Sarcopenia is increasingly recognised in patients with non-alcoholic liver disease (NAFLD). Initially recognised as a consequence of advanced liver disease, there is now emerging evidence that sarcopenia may be a novel risk factor for the development of NAFLD, with a role in fibrosis and disease progression.Areas covered: This review examines the epidemiology, pathogenesis and complex interplay between NAFLD and sarcopenia. Furthermore, the authors discuss the challenges with diagnosis of sarcopenia in the clinic and the evidence-based...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
CONCLUSIONS: If adequately counselled, women understand the consequences of excessive weight gain during pregnancy, comply more to therapy and modify their lifestyle. PMID: 32064826 [PubMed - in process]
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
CONCLUSIONS: Our data support the adoption of the surgical management of the morbidly obese patient. Although short term complication rates are higher with increasing obesity (II-III class), a majority of procedures can still be completed with minimally invasive approach. PMID: 32064825 [PubMed - in process]
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
Publication date: Available online 18 February 2020Source: Physiology &BehaviorAuthor(s): John E Blundell, Catherine Gibbons, Kristine Beaulieu, Nuno Casanova, Cristiana Duarte, Graham Finlayson, R James Stubbs, Mark HopkinsAbstractThe drive to eat is a component of appetite control, independent of the omnivorous habit of humans, and separate from food choice, satiety and food reward. The drive forms part of the tonic component of appetite and arises from biological needs; it is distinct from episodic aspects of appetite which are heavily influenced by culture and the environment (and which reflect the omnivorous habit...
Source: Physiology and Behavior - Category: Physiology Source Type: research
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