Simulation and optimization of reactive distillation for the production of ethyl acetate using BMIMHSO4 as catalyst
This study explicates the preparation of ethyl acetate (EtOAc) via esterification of acetic acid and ethanol over brønsted acid ionic liquid (1-Butyl-3-methylimidazolium hydrogen sulfate, [BMIM]HSO4) as catalyst. The ideal homogeneous (IH) and non-ideal homogeneous (NIH) models were applied to describe reaction kinetics and the model parameters were obtained by data fitting, where NIH model showed higher accuracy and confirmed the higher catalytic efficiency of [BMIM]HSO4 than Amberlyst 15. A novel reactive distillation (RD) flow-sheet for EtOAc production using [BMIM]HSO4 was designed and performed by Aspen Plus, in which the obtained reaction kinetic equations were formulated in the setting module of RADFRAC block. The optimal conditions of catalyst dosage, plate number, feed position, feed molar ratio, liquid holdup and reflux ratio for RD process were obtained by taking the EtOAc concentration in product stream as objective function and was found with maximum content of 90.44 wt.% with less than 3 % deviation. Keeping the high yield and simple mechanization, this approach can provide a feasible RD process design for EtOAc production using [BMIM]HSO4 as high-activity catalyst and can be envisaged as an alternative route for the industrial production of EtOAc.Graphical abstract
Publication date: Available online 26 February 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Anuja Pradeep, Asha Susan Geoji, Athira Elezebath George, V. Athira, Dilip Chandrasekhar, Saju Xavier, Jishnu Narayanan
Publication date: Available online 24 February 2020Source: American Journal of OtolaryngologyAuthor(s): Lei Wang, Gang Wang, Lianyong Li, Xin Fan, Hongdan Liu, Zhezhe Sun, Haolun Han, Baowei Li, Ruiying Ding, Wei Wu
Condition: GERD Interventions: Drug: JP-1366; Drug: JP-1366 placebo; Drug: Esomeprazole 40mg; Drug: Esomeprazole placebo Sponsor: Jeil Pharmaceutical Co., Ltd. Recruiting
Uterine fibroids affect up to 80% of reproductive-aged women. Although many women are asymptomatic, fibroids can cause pelvic pain, abnormal uterine bleeding, anemia, urinary frequency, infertility, and adverse pregnancy outcomes that can impair quality of life. Fifty percent of women with symptomatic fibroids report a detrimental impact on their mental and physical health (1). Fibroids appear to have a greater impact on quality of life than other chronic conditions, including asthma, irritable bowel syndrome, and gastroesophageal reflux disease (2).
AbstractThe aim of this study is to evaluate the incidence of vesicoureteral reflux (VUR) in patients with febrile convulsion (FC). For this, patients that were diagnosed with FC in 2018 were retrospectively reviewed. Those with epilepsy, motor/mental retardation, or spina bifida were excluded. Mid-stream urine samples were collected in children who were toilet trained while sterile bags were used in the smaller. Urinary tract infection (UTI) was defined as ˃ 5 leucocytes/HPF in urinalysis and a subsequent positive urine culture (≥ 10.000 CFU/ml). Children with UTI were further investigated via voiding cystourethrogram...
ConclusionsOur findings suggest that vonoprazan is non-inferior to PPIs as therapy for patients with GERD. Subgroup analysis indicates that vonoprazan is more effective than PPIs for patients with severe erosive esophagitis. The safety outcomes for vonoprazan are similar to those for PPIs.
Conclusions: Children with rumination syndrome have a distinct pattern of impedance-pH monitoring and can be distinguished amongst children presenting with refractory GERD. Applying a simple scoring system during impedance-pH analysis could lead to early diagnosis of children with rumination syndrome.
Journal of Perinatology, Published online: 21 February 2020; doi:10.1038/s41372-020-0630-4Prolonging gavage feeds for reduction of gastroesophageal reflux in infants
AbstractBackgroundGastro-esophageal reflux disease (GERD) can present with typical or atypical or laryngo-pharyngeal reflux (LPR) symptoms. Pulmonary aspiration of gastric refluxate is one of the most serious variants of reflux disease as its complications are difficult to diagnose and treat. The aim of this study was to establish predictors of pulmonary aspiration and LPR symptoms.MethodsRecords of 361 consecutive patient from a prospectively populated database were analyzed. Patients were categorized by symptom profile as predominantly LPR or GERD (98 GER and 263 LPR). Presenting symptom profile, pH studies, esophageal m...
CONCLUSION: Based on the results of studies of low-to-moderate quality, antireflux surgery improved QoL and reduced oesophageal acid exposure in NN and NI children in the short and medium term. Although antireflux surgery is a common elective operation, the lack of rigorous preoperative and postoperative evaluation(s) in the majority of patient-reported studies is striking. PMID: 32083325 [PubMed - as supplied by publisher]