Simulation and optimization of reactive distillation for the production of ethyl acetate using BMIMHSO4 as catalyst

This study explicates the preparation of ethyl acetate (EtOAc) via esterification of acetic acid and ethanol over brønsted acid ionic liquid (1-Butyl-3-methylimidazolium hydrogen sulfate, [BMIM]HSO4) as catalyst. The ideal homogeneous (IH) and non-ideal homogeneous (NIH) models were applied to describe reaction kinetics and the model parameters were obtained by data fitting, where NIH model showed higher accuracy and confirmed the higher catalytic efficiency of [BMIM]HSO4 than Amberlyst 15. A novel reactive distillation (RD) flow-sheet for EtOAc production using [BMIM]HSO4 was designed and performed by Aspen Plus, in which the obtained reaction kinetic equations were formulated in the setting module of RADFRAC block. The optimal conditions of catalyst dosage, plate number, feed position, feed molar ratio, liquid holdup and reflux ratio for RD process were obtained by taking the EtOAc concentration in product stream as objective function and was found with maximum content of 90.44 wt.% with less than 3 % deviation. Keeping the high yield and simple mechanization, this approach can provide a feasible RD process design for EtOAc production using [BMIM]HSO4 as high-activity catalyst and can be envisaged as an alternative route for the industrial production of EtOAc.Graphical abstract
Source: Chemical Engineering Research and Design - Category: Chemistry Source Type: research

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Publication date: Available online 26 February 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Anuja Pradeep, Asha Susan Geoji, Athira Elezebath George, V. Athira, Dilip Chandrasekhar, Saju Xavier, Jishnu Narayanan
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Publication date: Available online 24 February 2020Source: American Journal of OtolaryngologyAuthor(s): Lei Wang, Gang Wang, Lianyong Li, Xin Fan, Hongdan Liu, Zhezhe Sun, Haolun Han, Baowei Li, Ruiying Ding, Wei Wu
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Condition:   GERD Interventions:   Drug: JP-1366;   Drug: JP-1366 placebo;   Drug: Esomeprazole 40mg;   Drug: Esomeprazole placebo Sponsor:   Jeil Pharmaceutical Co., Ltd. Recruiting
Source: - Category: Research Source Type: clinical trials
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Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
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Source: Neurological Sciences - Category: Neurology Source Type: research
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Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
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Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
Journal of Perinatology, Published online: 21 February 2020; doi:10.1038/s41372-020-0630-4Prolonging gavage feeds for reduction of gastroesophageal reflux in infants
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
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Source: Esophagus - Category: Gastroenterology Source Type: research
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Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
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