Thirty-day postoperative morbidity in patients with breast cancer following neoadjuvant chemotherapy
The objective was to compare post-operative complication rates among patients treated with partial mastectomy (PM), unilateral mastectomy (UM), and bilateral mastectomy (BM) after NAC.
Dear colleagues, I would greatly appreciate your input on this situation. cT2N0 triple positive breast cancer. Mastectomy and axillary clearance after neoadjuvant chemotherapy shows pCR in the breast and sentinel node biopsy shows ITC. RT? Leave alone? Thanks
Background: Breast conserving surgery(BCS) is preferred over traditional mastectomy for better cosmetic and non-inferior oncological outcome. BCS is best indicated for early stage breast cancer with relatively small tumor size. Neo-adjuvant chemotherapy(NAC) helps downstaging locally advanced breast cancer and increase the possibility for BCS. However, recent meta-analysis from the Early Breast Cancer Trialists ’ Collaborative Group (EBCTCG) showed a higher locoregional recurrence(LLR) rate in the NAC group than in the adjuvant chemotherapy group.
This study explores the current role of SLNB in BC patients eligible for BCS, providing a view into future directions in BC care. PMID: 32975389 [PubMed - as supplied by publisher]
CONCLUSION: Our study provides novel insight into clinicopathological characteristics and treatment status among patients with IBC in China, and might provide a direction and basis for further studies. TRIAL REGISTRATION: chictr.org.cn, No. ChiCTR1900027179; http://www.chictr.org.cn/showprojen.aspx?proj=45030. PMID: 32925286 [PubMed - as supplied by publisher]
Abstract PURPOSE: To use pathologic indicators to determine which patients benefit from postmastectomy radiation therapy (PMRT) for breast cancer after neoadjuvant chemotherapy (NACT) and total mastectomy (TM). PATIENTS AND METHODS: We enrolled 4236 patients with breast invasive ductal carcinoma who received NACT followed by TM. Cox regression analysis was used to calculate hazard ratios (HRs) and confidence intervals; independent predictors were controlled for or stratified in the analysis. RESULTS: After multivariate Cox regression analyses, the adjusted HRs derived for PMRT for all-cause mortality wer...
Authors: Linhares S, Alrammah T, Alghamdi HA, Möller MG Abstract Inflammatory breast cancer (IBC) represents only 1% to 5% of all breast malignancies and is an extremely aggressive subtype. At time of diagnosis, up to 85% of patients will present with regional nodal metastases and up to 30 % will have metastasis to distant organs. There is limited medical literature describing treatment guidelines for IBC during gestation. The best diagnostic tools are core needle and full-thickness skin punch biopsies to assess presence of dermal lymphatic invasion. Breast Ultrasound is preferred to mammogram, but mammography...
Abstract Sentinel lymph node biopsy (SLNB) has emerged as an alternative to axillary lymph node dissection during breast cancer surgery during the last 2 decades. However, there are several controversies regarding the indication of the sentinel node biopsy after neoadjuvant chemotherapy which can convert positive lymph nodes to negative. The false negative rate after neoadjuvant chemotherapy is unacceptably high. This high false negative rate can be decreased by marking of the positive lymph nodes and removal during sentinel lymph node biopsy procedure in addition to the sentinel lymph nodes. The aim of this study...
Conclusion: Despite the fact that OS was performed in patients with worse tumour conditions and in more demanding patients, OS allowed similar cosmetic results to classical BCT.Breast Care
Conclusions: When histologic examination from the base of the nipple is negative (either by FS or permanent pathology), NSM can be considered oncologically safe. Lack of nipple involvement by preoperative clinical and imaging assessment and intraoperative FS is sufficient to classify patients as suitable for NSM.
Conclusions: PMRT might benefit pT1-2N1M0 patients with pN0 after NAC. Patients with pCR might consider omitting PMRT. Prospective studies are needed to assess the effect of PMRT on this specific patient population.