ACLY-matizing Macrophages to Histone Modification during Immunometabolic Reprogramming.

ACLY-matizing Macrophages to Histone Modification during Immunometabolic Reprogramming.
Trends Immunol. 2020 Jan 13;:
Authors: Williams NC, O'Neill LA
Abstract
Metabolic reprogramming in macrophages supports effector functions and differs depending on the activating stimulus. Lauterbach et al. now show that early metabolic alterations in macrophages driven by LPS signaling serve to increase the acetyl-CoA pool via citrate metabolism by the ATP-citrate lyase (ACLY), leading to histone acetylation and regulation of TLR-driven gene expression.
PMID: 31948874 [PubMed - as supplied by publisher]

Source: Trends in Immunology - January 12, 2020 Category: Allergy & Immunology Authors: Williams NC, O'Neill LA Tags: Trends Immunol Source Type: research