Value of epithelioid morphology and PDGFRA immunostaining pattern for prediction of PDGFRA mutated genotype in gastrointestinal stromal tumors (GISTs).

CONCLUSION: A combination of histomorphology and PDGFRA immunostaining is a reliable predictor of PDGFRA genotype in GIST. This approach allows direct selection of the "gene/exons of relevance" to be analyzed and may help to reduce costs and work load and shorten processing time of GIST genotyping by mutation analysis. PMID: 24040448 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/24040448?dopt=Abstract

Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Agaimy A, Otto C, Braun A, Geddert H, Schaefer IM, Haller F Tags: Int J Clin Exp Pathol Source Type: research