Interventions to Promote Resilience in Cancer Patients.

CONCLUSION: Interventions that promote resilience should be made available to inter- ested and motivated cancer patients. These interventions should be provided, in as soon as the diagnosis is made and should ex- tend over more than 12 sessions whenever possible. PMID: 31941574 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

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OBJECTIVES: Immune-nutritional status is correlated with a clinical outcome in critical illness. Recently, controlling nutritional status (CONUT) score and prognostic nutrition index (PNI) has been reported to predict prognosis following cancer and other d...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Accidents are the fourth cause of death, after heart disease, cancer and stroke, ±50 increases per year 100,000 population each year, 3% of the causes of death are due to direct spinal cord trauma, 2% due to multiple trauma. Attitudes or responses are ver...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
“My step-father abused me, and my mother is always telling me to forgive and forget.” Jodie shook her head ruefully. “And how is that going for you?” I ask. “Not so good,” Jodie replies, “I’m not doing a good job at all.” Alex shares, “My counselor told me if I don’t forgive my uncle for raping me, then I’m allowing him to live rent-free in my head.” “And how is that going for you?” I ask. “Not so good,” Alex cries, “I feel like I’m failing at recovery!” Both Jodie and Alex — and countless other sur...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Abuse PTSD Trauma Violence and Aggression Anger Forgiveness Rape Resentment Sexual Abuse Sexual Assault Sexual Trauma Source Type: blogs
Abstract Fear extinction is an important preclinical model for behavior therapy in human anxiety disorders, such as post-traumatic stress disorder (PTSD). Histone acetylation is involved in the extinction of fear memory. As the "readers" of histone acetylation markers, the role of the bromodomain and extraterminal domain (BET) proteins in fear extinction is still unclear. In the present study, we found that suppression of BET proteins using small molecule JQ-1 had no effects on the acquisition of auditory fear or on the extinction of recent auditory fear, but it impaired the extinction of remote auditory...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research
PURPOSE: Characterize prevalence of intimate partner violence (IPV) among breast and cervical survivors receiving care in an urban safety-net healthcare system; Examine the relationship between IPV and clinical characteristics, receipt of cancer treatment,...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons. Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractThere is a growing perception that DNA methylation may be influenced by exogenous and endogenous parameters. Knowledge of these factors is of great relevance for the interpretation of DNA-methylation data for the estimation of chronological age in forensic casework. We performed a literature review to identify parameters, which might be of relevance for the prediction of chronological age based on DNA methylation. The quality of age predictions might particularly be influenced by lifetime adversities (chronic stress, trauma/post-traumatic stress disorder (PTSD), violence, low socioeconomic status/education), cancer...
Source: International Journal of Legal Medicine - Category: Medical Law Source Type: research
Posttraumatic stress disorder (PTSD) is known to affect a subset of cancer survivors. Astudy inPsycho-Oncology found that 6.3% of young survivors of non-metastatic breast cancer reported PTSD symptoms related to cancer more than two years after their diagnosis. Women who reported anxiety symptoms six months after being diagnosed with breast cancer were 12 times more likely than others to report PTSD symptoms two years later.“We found similar rates of cancer-related PTSS [posttraumatic stress symptoms] in breast cancer survivors diagnosed at a young age compared with the general breast cancer population despite their ...
Source: Psychiatr News - Category: Psychiatry Tags: age at diagnosis anxiety breast cancer Danny Vazquez depression education posttraumatic stress disorder PTSD Checklist social support Young Women's Breast Cancer Study Source Type: research
Cancer patients are a population at high risk of contracting COVID-19 and, also of developing severe complications due to the infection, which is especially true when they are undergoing immunosuppressive treatment. Despite this, they had still to go to hospital to receive chemotherapy during lockdown. In this context, we have evaluated the psychological status of onco-hematological outpatients receiving infusion and not deferrable anti-neoplastic treatment for lymphoproliferative neoplasms, with the aim of both measuring the levels of post-traumatic symptoms, depression, and anxiety during the pandemic and also of investi...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Abstract Mediation analysis has been a useful tool for investigating the effect of mediators that lie in the path from the independent variable to the outcome. With the increasing dimensionality of mediators such as in (epi)genomics studies, high-dimensional mediation model is needed. In this work, we focus on epigenetic studies with the goal to identify important DNA methylations that act as mediators between an exposure disease outcome. Specifically, we focus on gene-based high-dimensional mediation analysis implemented with kernel principal component analysis to capture potential nonlinear mediation effect. We ...
Source: Briefings in Bioinformatics - Category: Bioinformatics Authors: Tags: Brief Bioinform Source Type: research
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