Palladium/aluminium-cocatalyzed carbonylative synthesis of 2-chloroethyl benzoates from epoxides and aryl iodides

Publication date: Available online 16 January 2020Source: Journal of Organometallic ChemistryAuthor(s): Xinxin Qi, Zhi-Peng Bao, Chen-Yang Hou, Wei-Feng Wang, Xiao-Feng WuAbstractA new straightforward and efficient procedure for the palladium/aluminium-cocatalyzed carbonylative synthesis of 2-chloroethyl benzoates from epoxides and aryl iodides has been developed. By using TFBen (benzene-1,3,5-triyl triformate) as the CO source and LiCl as the chloride source, AlCl3-catalyzed regioselective ring-opening of epoxides was merged successfully with the palladium-catalyzed carbonylative cross-coupling of aryl iodides. A variety of the desired 2-chloroethyl benzoates were obtained in moderate to excellent yields with very good substrates compatibility.Graphical abstract

Source: Journal of Organometallic Chemistry - January 17, 2020 Category: Chemistry Source Type: research