How Does Narcolepsy Impact Health-Related Quality of Life? A Mixed-Methods Study.

How Does Narcolepsy Impact Health-Related Quality of Life? A Mixed-Methods Study. Behav Sleep Med. 2020 Jan 14;:1-14 Authors: Ong JC, Fox RS, Brower RF, Mazurek S, Moore C Abstract Study Objectives: The purpose of this study was to identify patient-centered issues affecting Health-Related Quality of Life (HRQoL) in people with narcolepsy (PWN) and to evaluate patient-reported outcome measures using a mixed-methods approach.Methods: Twenty-nine adults (93% female, mean age = 31 years) with an established diagnosis of narcolepsy (Type I = 58.6%) completed focus group interviews using live videoconferencing. Additionally, participants completed the Patient-Reported Outcomes Measurement Information System (PROMIS) measures along with legacy measures commonly used in narcolepsy research (Epworth Sleepiness Scale, Patient Health Questionnaire, Short-Form 36).Results: Thematic analysis of qualitative data revealed that HRQoL was impacted by the constancy of sleepiness, unpredictability of narcolepsy symptoms, and negative public perception of narcolepsy. Challenges to accessibility and/or quality of care included dissatisfaction with non-sleep specialists' understanding of narcolepsy, the unpredictability of symptoms, and the cost of health care. There was enthusiasm for developing a psychosocial intervention to improve HRQoL using online access, but there were mixed opinions regarding the format, provider background, and content of the inte...
Source: Behavioral Sleep Medicine - Category: Sleep Medicine Authors: Tags: Behav Sleep Med Source Type: research

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_______ The all-too-understandable urge to buy a better brain (Vox): “… unfortunately, Bradley Cooper is partly to blame for the boom of the edible brain-improvement industry. In 2011, he starred in Limitless, a movie about a man who takes a special pill and becomes smarter and more capable than anyone else on Earth. I’m joking about the cultural significance of this movie, but I’m also not. It was a wild card and an unexpected hit, and it mainstreamed an idea that had already been taking hold among Silicon Valley biohackers and human optimization zealots. (TechCrunch called the prescription-only n...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness brain brain health Brain-Fitness brain-improvement brain-improvement industry dietary supplements Limitless mental-fitness modafinil nootropics Source Type: blogs
Abstract PURPOSE: This case-control study assessed the prevalence of psychiatric disorders in Arab (Saudi) patients with narcolepsy using a structured clinical interview. METHODS: The study included 74 adult patients with narcolepsy and 265 controls matched for age and sex. Narcolepsy diagnosis was made according to the International Classification of Sleep Disorders-Third Edition. Psychiatric disorders were diagnosed via using a validated Arabic version of the Mini International Neuropsychiatric Interview DSM-IV (MINI version 6). A multivariate logistic regression model was used to assess the potential ...
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
AbstractPurposeThis case-control study assessed the prevalence of psychiatric disorders in Arab  (Saudi) patients with narcolepsy using a structured clinical interview.MethodsThe study included 74 adult patients with narcolepsy and 265 controls matched for age and sex. Narcolepsy diagnosis was made according to the International Classification of Sleep Disorders-Third Edition. Psychiatric disorders were diagnosed via using a validated Arabic version of the Mini International Neuropsychiatric Interview DSM-IV (MINI version 6). A multivariate logistic regression model was used to assess the potential influence of narcol...
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
This study indicated that switch from H2 blockers to PPIs reduced delirium and, thus, providing an appropriate strategy to combat drug-induced delirium using antiulcer drugs (Fujii et al., 2012). The ventrolateral preoptic nucleus is a sleep-promoting nucleus located in the basal forebrain. A commonly used intravenous anesthetic, propofol, had been reported to induce sleep and augment the firing rate of neurons in ventrolateral GABAergic preoptic nucleus, but the underlining mechanism is yet to be clearly determined. Interestingly, the propofol-induced inhibition of inhibitory postsynaptic currents on noradrenalin-inhibite...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
We report four children with narcolepsy type 1 (NT1) and autism spectrum disorder (ASD) - Asperger syndrome (AS). To the best of our knowledge co-occurrence of NT1 and AS has not been described in the literature.
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: Brief Communication Source Type: research
Publication date: June 2018Source: Pharmacology &Therapeutics, Volume 186Author(s): Hiroshi Tsuneki, Tsutomu Wada, Toshiyasu SasaokaAbstractSleep, a mysterious behavior, has recently been recognized as a crucial factor for health and longevity. The daily sleep/wake cycle provides the basis of biorhythms controlling whole-body homeostasis and homeodynamics; therefore, disruption of sleep causes several physical and psychological disorders, including cardiovascular disease, obesity, diabetes, cancer, anxiety, depression, and cognitive dysfunction. However, the mechanism linking sleep disturbances and sleep-related disord...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple scleros...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research
Publication date: Available online 29 December 2017 Source:Pharmacology & Therapeutics Author(s): Hiroshi Tsuneki, Tsutomu Wada, Toshiyasu Sasaoka Sleep, a mysterious behavior, has recently been recognized as a crucial factor for health and longevity. The daily sleep/wake cycle provides the basis of biorhythms controlling whole-body homeostasis and homeodynamics; therefore, disruption of sleep causes several physical and psychological disorders, including cardiovascular disease, obesity, diabetes, cancer, anxiety, depression, and cognitive dysfunction. However, the mechanism linking sleep disturbances and sleep-relate...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Introduction: Childhood narcolepsy is associated with various emotional, behavioural and cognitive dysfunctions as well as with psychiatric and neurodevelopmental disorders: anxiety, depression, attention deficit hyperactivity disorder and psychosis. A relationship between these conditions is not clear –comorbidity as well as similar pathophysiological mechanisms can be suggested. The aim of our study is to describe four children with narcolepsy type 1 (NT1) and new comorbidity of autism spectrum disorder (ASD)–Asperger syndrome.
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: Narcolepsy Source Type: research
Happy Saturday, sweet readers! Can you believe it’s the last weekend of August? I know summer doesn’t technically end as soon as August is over, but…where did the summer go?! Well, before you head out to enjoy the weekend, take some time to catch up on the science of spirituality, why having a best friend as a teenager helps develop a sense of self later in life, how winning the lottery will contribute little to your level of happiness, and more. The Science of Spirituality: A Psychologist and a Neuroscientist Explain Being ‘In The Flow’: Although spirituality is making a big mainstream come...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Alzheimer's Anxiety and Panic Autism Brain and Behavior Children and Teens Depression Friends Happiness Health-related Memory and Perception Money and Financial OCD Psychology Psychology Around the Net Research Spirituality Source Type: blogs
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