BCG-induced trained immunity in macrophage: reprograming of glucose metabolism.

BCG-induced trained immunity in macrophage: reprograming of glucose metabolism. Int Rev Immunol. 2020 Jan 14;:1-14 Authors: Liu Y, Liang S, Ding R, Hou Y, Deng F, Ma X, Song T, Yan D Abstract Memory is no longer a privilege of adaptive immunity. Innate immune cells can exhibit a long-term immune activation after infection or vaccination, which is called "trained immunity." In addition to defense against mycobacterial infection, BCG-induced trained immunity can also exert nonspecific protection, which is regulated by metabolic rewiring and epigenetic reprograming. Enhanced glycolysis and glutamine-driven tricarboxylic acid cycle have been proven to be important metabolic pathways for trained immunity induced by BCG, which is dependent on Akt/mTOR pathway. PMID: 31933415 [PubMed - as supplied by publisher]
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research