Increased Expression of Delta-like Ligand 4 in Mycosis Fungoides.

This study investigated the roles of Delta-like ligand 4 in mycosis fungoides. Delta-like ligand 4 mRNA levels in lesional skin of patients with mycosis fungoides were significantly elevated compared with those of normal controls, and correlated with disease-specific mortality. Immunohistochemical staining demonstrated prominent expression of Delta-like ligand 4 on vascular endothelial cells and tumour cells in mycosis fungoides lesional skin. In addition, Delta-like ligand 4 augmented the proliferation of cutaneous T-cell lym-phoma cell lines. These results suggest that enhanced Delta-like ligand 4 expression may contribute directly to the progression of mycosis fungoides through proliferating tumour cells.
PMID: 31930426 [PubMed - as supplied by publisher]

Source: Acta Dermato-Venereologica - January 12, 2020 Category: Dermatology Authors: Boki H, Miyagaki T, Shono Y, Kamijo H, Oka T, Suga H, Asano Y, Sugaya M, Sato S Tags: Acta Derm Venereol Source Type: research