Interaction of epidermal growth factor with COX-2 products and peroxisome proliferator-activated receptor gamma system in experimental rat Barrett's esophagus.

Interaction of epidermal growth factor with COX-2 products and peroxisome proliferator-activated receptor gamma system in experimental rat Barrett's esophagus. Am J Physiol Gastrointest Liver Physiol. 2020 Jan 13;: Authors: Majka J, Wierdak M, Szlachcic A, Magierowski M, Targosz A, Urbanczyk K, Krzysiek-Maczka G, Ptak-Belowska A, Bakalarz D, Magierowska K, Chmura A, Brzozowski T Abstract Mixed acidic-alkaline refluxate is a major pathogenic factor in chronic esophagitis progressing into Barrett's esophagus (BE) but the involvement of epidermal growth factor (EGF), COX-2 and peroxisome proliferator-activated receptor gamma (PPARg) in BE has not been extensively studied. Rats surgically prepared with esophagogastroduodenal anastomosis (EGDA) with intact or removed salivary glands to deplete salivary EGF were treated either with: 1) vehicle, 2) EGF or pioglitazone with or without tyrphostin A46 or GW9662, respectively, 3) ranitidine or pantoprazole. At three months, the esophageal damage (LI) and the esophageal blood flow (EBF) were determined, and the mucosal expression of EGF, EGFR, COX-2, TNF-α and PPARγ mRNA was analyzed. All EGDA animals developed chronic esophagitis, esophageal ulcerations and intestinal metaplasia followed by the fall in the EBF, an increase in the plasma IL-1β and TNF-α levels, the rise in the mucosal PGE2 content and the overexpression of COX-2-, EGF- and EGFR mRNAs and these effects were aggravated by EGF ...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - Category: Physiology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research