A rare cause of obstructive jaundice: Is surgery the only option?

Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research

Related Links:

Biliary atresia (BA), which is the most important cause of liver cirrhosis in children, is characterized by progressive fibro-obliterative inflammation involving the extra- and intrahepatic bile ducts in infancy.1 A successful Kasai portoenterostomy procedure establishes bile drainage and may  prevent hepatic fibrogenesis and the need for liver transplantation. However, the procedure is unsuccessful in a significant portion of patients, who have persistent jaundice and liver dysfunction. Intestinal bile acids modulate the gut microbiota and may have a role in disease progression in BA.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Short Communication Source Type: research
In this study, we first analyzed the chemical compounds of AG by HPLC-DAD-ESI-IT-TOF-MS n . Of the 31 compounds detected, 29 were identified based on previous results. Then, the effects of DMY and AG on high-fat diet hamster livers were studied and the metabolite levels and metabolic pathway activity of the liver were explored by 1H NMR metabolomics. Compared to the high-fat diet group, supplementation of AG and DMY attenuated the high-fat-induced increase in body weight, liver lipid deposition, serum triglycerides and total cholesterol levels, and normalized endogenous metabolite concentrations. PCA and PLS-DA score plots...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
ConclusionYCZFD administration ameliorated disordered bile acid homeostasis, inhibited NF-κB pathway-mediated inflammation, and protected the liver from bile duct injury. Therefore, YCZFD exerted a protective effect against cholestatic liver injury.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 17 February 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Gulim Murzakanova, Sari Räisänen, Anne Flem Jacobsen, Kristina Baker Sole, Lisa Bjarkø, Katariina LaineAbstractObjectiveTo assess the prevalence and risk of adverse perinatal outcomes in early-term (37+0–38+6 weeks), full-term (39+0–40+6 weeks), late-term (41+0–41+6 weeks), and post-term (>42+0 weeks) deliveries with spontaneous labor onset.Study designA population-based cohort with data from the Medical Birth Registry Norway (MBRN) and Statistics...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Conditions:   Hepatic Echinococcosis;   Jaundice Intervention:   Sponsors:   Universidad de Extremadura;   Complejo Hospitalario Universitario de Badajoz Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 15 February 2020Source: Toxicology ReportsAuthor(s): Hellen A. Oketch-Rabah, Amy L. Roe, Cynthia V. Rider, Herbert L. Bonkovsky, Gabriel I. Giancaspro, Victor Navarro, Mary F. Paine, Joseph M. Betz, Robin J. Marles, Steven Casper, Bill Gurley, Scott A. Jordan, Kan He, Mahendra P. Kapoor, Theertham P. Rao, Averell H. Sherker, Robert J. Fontana, Simona Rossi, Raj Vuppalanchi, Leonard B. SeeffABSTRACTAs part of the United States Pharmacopeia’s ongoing review of dietary supplement safety data, a new comprehensive systematic review on green tea extracts (GTE) has been completed. GTEs may...
Source: Toxicology Reports - Category: Toxicology Source Type: research
Soares Albuquerque Indiara Penido Tayrine Araujo Santos Ana Paula Dinis Ano Bom Andrea Marques Vieira da Silva Camilla Bayma Fernandes Carlos Eduardo Calzavara Erna Geessien Kroon Olindo Assis Martins-Filho Andréa Teixeira-Carvalho Betânia Paiva Drumond One patient presented hyporexia, asthenia, adynamia, and jaundice two months after acute yellow fever (YF) onset; plus laboratory tests indicating hepatic cytolysis and a rebound of alanine and aspartate transaminases, and total and direct bilirubin levels. Laboratory tests discarded autoimmune hepatitis, inflammatory or metabolic liver ...
Source: Viruses - Category: Virology Authors: Tags: Case Report Source Type: research
Conditions:   Hepatic Echinococcosis;   Jaundice Intervention:   Sponsors:   Universidad de Extremadura;   Complejo Hospitalario Universitario de Badajoz Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The objective of this case report is to share the uncommon side effect of taking this traditional product which may have been under-reported due to the unknown effect. PMID: 32041919 [PubMed - in process]
Source: Acta medica Indonesiana - Category: Internal Medicine Tags: Acta Med Indones Source Type: research
Source: ScienceNOW - Category: Science Authors: Tags: twis Source Type: news
More News: Gastroenterology | Jaundice