CD4+ T cells as key players in the immunopathology of Takayasu's arteritis: Comments on the article by Zhang et al

AbstractI read the article by Zhang et al. published in this journal with great interest (1). They demonstrated that CD4+ T cells isolated from Takayasu's arteritis (TAK) are biased to differentiate into Th1 and Th17 cells because of mechanistic target of rapamycin complex 1 (mTORC1) hyperactivity. Subsequently, using human artery ‐NSG chimera model, they showed that mTORC1 inhibition, by either rapamycin or RNAi technology, effectively abrogated the mal‐differentiation of TAK CD4+ T cells and vascular inflammation.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: LETTER TO THE EDITOR Source Type: research