Trafficking of non-esterified fatty acids in insulin resistance and relationship to dys-glycemia.

Trafficking of non-esterified fatty acids in insulin resistance and relationship to dys-glycemia. Am J Physiol Endocrinol Metab. 2020 Jan 07;: Authors: Walker RE, Ford JL, Boston RC, Savinova OV, Harris WS, Green MH, Shearer GC Abstract In adipose, insulin functions to suppress intracellular lipolysis and secretion of non-esterified fatty acid (NEFA) into plasma. Current tests of insulin resistance do not test this response. We applied glucose and NEFA minimal models (MM) following a frequently sampled intravenous glucose tolerance test (FSIVGTT) to assess glucose-specific and NEFA-specific insulin resistance. We used total NEFA and individual fatty acids in the NEFA MM, comparing the model parameters in metabolic syndrome (MetSyn) subjects (N=52) with optimally healthy controls (OptHC) (N=14). Results are reported as mean difference (95% CI). Using the glucose MM, MetSyn subjects had lower [-73% (-82, -57)] sensitivity to insulin (Si) and higher [138% (44, 293)] acute insulin response to glucose (AIRg). Using the NEFA MM, MetSyn subjects had lower [-24% (-35, -13)] % suppression, higher [32% (15, 52)] threshold glucose (gs), and a higher [81% (12, 192)] affinity constant altering NEFA secretion (Φ). Comparing fatty acids, % suppression was lower in myristic acid (MA) than all other fatty acids, and the stearic acid (SA) response was so unique that it did not fit the NEFA MM. MA and SA % of total were increased at 50 minutes after g...
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research