Dose-Dependent Growth Delay of Breast Cancer Xenografts in the Bone Marrow of Mice Treated with 223Ra: The Role of Bystander Effects and Their Potential for Therapy

Conclusion: Taken together, these results support the participation of 223Ra-induced antiproliferative/cytotoxic bystander effects in delayed growth of DTC xenografts. They indicate that the delay depends on the injected activity and therefore is dose-dependent. They suggest using 223RaCl2 as an adjuvant treatment for select patients at early stages of breast cancer.

Source: Journal of Nuclear Medicine - January 1, 2020 Category: Nuclear Medicine Authors: Leung, C. N., Canter, B. S., Rajon, D., Back, T. A., Fritton, J. C., Azzam, E. I., Howell, R. W. Tags: Basic Source Type: research