Ca2+/CaM interaction with voltage-gated Na+ channels [Biological Sciences]

Gardill et al. (1) describe a crystal structure for a complex of Ca2+-loaded calmodulin (CaM) and the cardiac NaV1.5 Na+ channel intracellular C terminus (C-terminal domain [CTD]) (Protein Data Bank [PDB]: 6MUD). They found, as we reported (2) with ternary complexes (PDB: 4JQ0 and 4JPZ) of NaVCTD, Ca2+-CaM, and the...

Source: Proceedings of the National Academy of Sciences - December 25, 2019 Category: Science Authors: Geoffrey S. Pitt, Seok-Yong Lee Tags: Letters Source Type: research