Zirconium metal-organic framework assisted miniaturized solid phase extraction of phenylurea herbicides in natural products by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

Publication date: Available online 23 December 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Qiu-Yan Wang, Juan Yang, Xin Dong, Yan Chen, Li-Hong Ye, Yu-Han Hu, Hui Zheng, Jun CaoAbstractThe zirconium metal-organic framework (Zr-MOF) was used as a novel and effective adsorbent material for the enrichment of five phenylurea herbicides (fenuron, monuron, diuron, linuron and pencycuron) in Dendrobii Officinalis Caulis, Salviae Miltiorrhizae Radix et Rhizoma and Hawthorn samples. The target analytes were determined by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Some crucial experimental parameters, such as type of adsorbents, amount of adsorbent, type of eluent solvents and adsorption capacity were investigated and optimized. Under the optimum extraction conditions, the enrichment factors of fenuron, monuron, diuron, linuron and pencycuron were 90, 128, 148, 204 and 295 times, respectively. A good linearity was obtained in different concentration levels of target analytes with the determination coefficients (r2) larger than 0.993. In addition, the limits of detection varied from 0.05 to 0.36 ng/mL and the recoveries of the analytes were in the range of 85.19-99.13%. The results demonstrated that the proposed miniaturized solid-phase extraction procedure coupled with Zr-MOF could become an effective tool to analyze phenylurea herbicides and would have the vast application prospect for the extra...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research