A new metabolite from Cunninghamella blakesleeana-mediated biotransformation of an oral contraceptive drug, levonorgestrel.

A new metabolite from Cunninghamella blakesleeana-mediated biotransformation of an oral contraceptive drug, levonorgestrel.
Nat Prod Res. 2019 Dec 17;:1-4
Authors: Kudaibergenova BM, Wahab AT, Siddiqui M, Abilov ZA, Choudhary MI
Abstract
Cunninghamella blakesleeana-mediated biotransformation of an oral contraceptive drug, levonorgestrel (1), yielded a new metabolite, 13β-ethyl-17α-ethynyl-10,17β-dihydroxy-4,6-dien-3-one (2), and two known metabolites 3 (13β-ethyl-17α-ethynyl-10β,17β-dihydroxy-4-en-3-one), and 4 (13β-ethyl-17α-ethynyl-6β,17β-dihydroxy-4-en-3-one) at an ambient temperature using aqueous media. Hydroxylation and dehydrogenation of compound 1 was observed during the bio-catalytic transformation. The structure of a new metabolite 2 was determined by 1H, 13C, and 2DNMR and HR-EIMS spectroscopic techniques.
PMID: 31845608 [PubMed - as supplied by publisher]

Source: Natural Product Research - December 16, 2019 Category: Biochemistry Authors: Kudaibergenova BM, Wahab AT, Siddiqui M, Abilov ZA, Choudhary MI Tags: Nat Prod Res Source Type: research