HRT containing oestrogen may cut the risk of breast cancer but pills with progesterone INCREASE risk

More than 27,000 women in the US were given a hormone replacement therapy or a placebo - oestrogen-only HRT was found to reduce cancer risk by 23 per cent while combined HRT raised it.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Source: BMJ Comments - Category: General Medicine Source Type: forums
There are many risk factors associated with breast cancer (BC) such as the familial history of BC, using hormone replacement therapy, obesity, personal habits, and other clinical factors; however, not all BC cases are attributed to these risk factors. Recent researches show a correlation between patient microbiome and BC suggested as a new risk factor. The present review article aimed at evaluating the role of the microbiome as a risk factor in the occurrence of BC, investigating the proposed mechanisms of interaction between the microbiome and human genes involved in BC, and assessing the impact of the altered composition...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
We present noninvasive imaging of estrogen receptors with 99mTc tamoxifen that can identify the active tumor and approachable sites for biopsy. It may help in selection of patients for hormone replacement therapy and in assessment of receptor status in recurrent disease and also in response evaluation.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
CONCLUSIONS: Hormone replacement therapy may slightly improve overall survival in women who have undergone surgical treatment for EOC, but the certainty of the evidence is low. HRT may make little or no difference to quality of life, incidence of breast cancer, TIA, CVA and MI as the certainty of the evidence has been assessed as very low. There may be little or no effect of HRT use on progression-free survival. The evidence in this review is limited by imprecision and incompleteness of reported relevant outcomes and therefore the results should be interpreted with caution. Future well-designed RCTs are required as this is...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Excess body weight is an established risk factor for breast cancer. Research suggests that’s because too much body fat can elevate levels of sex hormones like estrogen, especially among postmenopausal women. But despite knowing there is a correlation between extra weight and breast cancer, it’s been difficult to study how losing that weight could affect an individual woman’s chance of developing cancer. Now, a new paper published in the Journal of the National Cancer Institute provides encouraging evidence that, for women 50 and older, virtually any amount of sustained weight loss translates to a reductio...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer embargoed study Source Type: news
FRIDAY, Dec. 13, 2019 -- The ongoing debate about postmenopausal hormone therapy and breast cancer risk may have turned even more muddy: A large, new study suggests that two different types of hormone therapy have opposite effects on women's...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
This study was conducted in 263,788 women aged 40–69 years at enrolment into the UK Biobank population-based cohort. Information on demographic, reproductive and health factors was collected at baseline using computerized questionnaires, while incident DCIS was ascertained through linkage to UK cancer registries. Age-adjusted and multivariable hazard ratios were estimated using Cox proportional hazards models in the total sample and by menopausal status. During an average of 7 years of follow-up, 1,016 women developed DCIS. Multivariable analysis indicated that age, physical activity, height, family history of breast...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 7 November 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Meletios P. Nigdelis, Irene Lambrinoudaki, Dimitrios G. Goulis
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
This study investigated changes in women’s risk factor awareness between 2004 and 2016. Results from a 2004 survey of 2107 healthy women were compared with new data obtained using the same questionnaire in 2016, with 866 participants indicating their knowledge and perceptions regarding breast cancer incidence, risk factors, risk perceptions, and levels of concern. Logistic regression models assessed the influence of time point (2004 vs. 2016) on correct recognition of risk factors such as age at first childbirth, childlessness, lack of breastfeeding, hormone replacement therapy (HRT), and family history. Regression m...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research
Abstract Hormone replacement therapy (HRT) remains the most effective treatment for menopausal symptoms and has been shown to prevent bone loss and fracture. The progestogen is added to provide endometrial protection in women with an intact uterus. After the publication of the initial WHI (Women's Health Initiative) results in 2002 reporting an overall increased risk of breast cancer, many women discontinued HRT. Despite the re-analysis of the results by subgroups of patients and updates with extended follow-up, much controversy remains, which we will analyze later in the text. Different types of estrogen or proge...
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
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