Multi-Institutional Evaluation of Inter-rater Agreement of Variant Classification Based on the 2017 AMP, ASCO and CAP Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer

This multi-institutional study was undertaken to evaluate inter-rater reliability of the 2017 AMP/ASCO/CAP guidelines for interpretation and reporting of oncology sequence variants and to assess current practices and perceptions surrounding these guidelines. Fifty-one variants were distributed to 20 participants from 10 institutions for classification using the new guidelines. Agreement was assessed using chance corrected agreement (Cohen ’s kappa). Overall chance corrected agreement (kappa) was 0.35.

Source: Journal of Molecular Diagnostics - December 10, 2019 Category: Pathology Authors: Deepika Sirohi, Robert L. Schmidt, Dara L. Aisner, Amir Behdad, Bryan L. Betz, Noah Brown, Joshua F. Coleman, Christopher L. Corless, Georgios Deftereos, Mark D. Ewalt, Helen Fernandes, Susan J. Hsiao, Mahesh M. Mansukhani, Sarah S. Murray, Nifang Niu, La Source Type: research